Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.

Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.

Regulation of poly(ADP-ribose) (PAR) synthesis and turnover is critical to determining cell fate after genotoxic stress. Hyperactivation of PAR synthesis by poly(ADP-ribose) polymerase-1 (PARP-1) occurs when cells deficient in DNA repair are exposed to genotoxic agents; however, the function of this...

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Bibliographic Details
Main Authors: Natalie R Gassman, Donna F Stefanick, Padmini S Kedar, Julie K Horton, Samuel H Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3492265?pdf=render

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http://europepmc.org/articles/PMC3492265?pdf=render

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