Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.
Regulation of poly(ADP-ribose) (PAR) synthesis and turnover is critical to determining cell fate after genotoxic stress. Hyperactivation of PAR synthesis by poly(ADP-ribose) polymerase-1 (PARP-1) occurs when cells deficient in DNA repair are exposed to genotoxic agents; however, the function of this...
Main Authors: | Natalie R Gassman, Donna F Stefanick, Padmini S Kedar, Julie K Horton, Samuel H Wilson |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3492265?pdf=render |
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