Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice

Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice

Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6 overexpression increases resistance to colitis...

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Bibliographic Details
Main Authors:	Kang Xu, Yannan Guo, Lu Ping, Ying Qiu, Qingfei Liu, Zhongchi Li, Zhao Wang
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Cells
Subjects:	SIRT6 colitis inflammation NF-κB and c-Jun signaling TAK1
Online Access:	https://www.mdpi.com/2073-4409/9/6/1513

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