The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption
Abstract Background Chronic hepatitis B virus (HBV) infection-reduced liver functions are associated with intestinal microbial community dissimilarity. This study aimed to investigate the microbial community dissimilarity in patients with different grades of HBV-related liver cirrhosis. Results Seru...
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doaj-50a0fbf666c0409881c18cf8ab918fea2020-11-25T00:04:25ZengBMCGut Pathogens1757-47492019-11-0111111310.1186/s13099-019-0337-2The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumptionYong-Dong Deng0Xue-Bin Peng1Rong-Rong Zhao2Chao-Qun Ma3Jian-ning Li4Li-Qiong Yao5Department of Infection, First Hospital of Lanzhou UniversityDepartment of Infection, First Hospital of Lanzhou UniversityDepartment of Infection, First Hospital of Lanzhou UniversityFirst Clinical Medicine of Lanzhou University, Medical College of Lanzhou UniversityDepartment of Infection, First Hospital of Lanzhou UniversityDepartment of Laboratory, First Hospital of Lanzhou UniversityAbstract Background Chronic hepatitis B virus (HBV) infection-reduced liver functions are associated with intestinal microbial community dissimilarity. This study aimed to investigate the microbial community dissimilarity in patients with different grades of HBV-related liver cirrhosis. Results Serum endotoxin was increased with Child–Pugh (CP) class (A, B, and C). Veillonellaceae and Lachnospiraceae families were reduced in patients compared with controls. Megamonas and Veillonella genus was reduced and increased in patients compared with controls, respectively, especially in CPB and CPC groups. Correlation analysis showed that endotoxin content was significantly correlated with alcohol consumption (95% CI 0.100, 0.493), CP class (95% CI 0.289, 0.687) and Lachnospiraceae family level (95% CI − 0.539, − 0.122). Firmicutes/Bacteroidetes ratio was correlated with the level of Lachnospiraceae family (95% CI 0.013, 0.481), Veillonellaceae family (95% CI 0.284, 0.696), Megamonas genus (95% CI 0.101, 0.518) and Veillonella genus (95% CI 0.134, 0.545). All aforementioned bacteria were independent risk or protective factors for hepatitis. Alcohol consumption changed microbial community. Conclusions Our study demonstrated that elevated Firmicutes/Bacteroidetes ratio, reduced Megamonas genus level and increased Veillonella genus level were indicators for HBV-related liver cirrhosis. Alcohol-related pathogenesis was associated with the changed microbial community.http://link.springer.com/article/10.1186/s13099-019-0337-2Hepatitis B virus-related liver cirrhosisIntestinal microbiota16S rRNA gene sequencingChild–Pugh class |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong-Dong Deng Xue-Bin Peng Rong-Rong Zhao Chao-Qun Ma Jian-ning Li Li-Qiong Yao |
spellingShingle |
Yong-Dong Deng Xue-Bin Peng Rong-Rong Zhao Chao-Qun Ma Jian-ning Li Li-Qiong Yao The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption Gut Pathogens Hepatitis B virus-related liver cirrhosis Intestinal microbiota 16S rRNA gene sequencing Child–Pugh class |
author_facet |
Yong-Dong Deng Xue-Bin Peng Rong-Rong Zhao Chao-Qun Ma Jian-ning Li Li-Qiong Yao |
author_sort |
Yong-Dong Deng |
title |
The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption |
title_short |
The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption |
title_full |
The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption |
title_fullStr |
The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption |
title_full_unstemmed |
The intestinal microbial community dissimilarity in hepatitis B virus-related liver cirrhosis patients with and without at alcohol consumption |
title_sort |
intestinal microbial community dissimilarity in hepatitis b virus-related liver cirrhosis patients with and without at alcohol consumption |
publisher |
BMC |
series |
Gut Pathogens |
issn |
1757-4749 |
publishDate |
2019-11-01 |
description |
Abstract Background Chronic hepatitis B virus (HBV) infection-reduced liver functions are associated with intestinal microbial community dissimilarity. This study aimed to investigate the microbial community dissimilarity in patients with different grades of HBV-related liver cirrhosis. Results Serum endotoxin was increased with Child–Pugh (CP) class (A, B, and C). Veillonellaceae and Lachnospiraceae families were reduced in patients compared with controls. Megamonas and Veillonella genus was reduced and increased in patients compared with controls, respectively, especially in CPB and CPC groups. Correlation analysis showed that endotoxin content was significantly correlated with alcohol consumption (95% CI 0.100, 0.493), CP class (95% CI 0.289, 0.687) and Lachnospiraceae family level (95% CI − 0.539, − 0.122). Firmicutes/Bacteroidetes ratio was correlated with the level of Lachnospiraceae family (95% CI 0.013, 0.481), Veillonellaceae family (95% CI 0.284, 0.696), Megamonas genus (95% CI 0.101, 0.518) and Veillonella genus (95% CI 0.134, 0.545). All aforementioned bacteria were independent risk or protective factors for hepatitis. Alcohol consumption changed microbial community. Conclusions Our study demonstrated that elevated Firmicutes/Bacteroidetes ratio, reduced Megamonas genus level and increased Veillonella genus level were indicators for HBV-related liver cirrhosis. Alcohol-related pathogenesis was associated with the changed microbial community. |
topic |
Hepatitis B virus-related liver cirrhosis Intestinal microbiota 16S rRNA gene sequencing Child–Pugh class |
url |
http://link.springer.com/article/10.1186/s13099-019-0337-2 |
work_keys_str_mv |
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