Full-length title: NRPPUR database search and in vitro analysis identify an NRPS-PKS biosynthetic gene cluster with a potential antibiotic effect

Full-length title: NRPPUR database search and in vitro analysis identify an NRPS-PKS biosynthetic gene cluster with a potential antibiotic effect

Abstract Background Growing concern about the emergence of antibiotic resistance is compelling the pharmaceutical industry to search for new antimicrobial agents. The availability of genome sequences has enabled the development of computational mining as an important tool in the discovery of natural...

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Bibliographic Details
Main Authors: Shirley Fritz, Andriamiharimamy Rajaonison, Olivier Chabrol, Didier Raoult, Jean-Marc Rolain, Vicky Merhej
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Bioinformatics
Subjects:
NRPPUR database
NRPS-PKS biosynthetic gene cluster
Natural antibiotic
Genome mining
Human gut microbiota
In vitro analysis
Online Access:http://link.springer.com/article/10.1186/s12859-018-2479-5

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