Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study

Rania Abd El-Hamid El-Kady,1,2 Dania Waggas,2 Ahmed AkL3,4 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Department of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia; 3Department of Nephrol...

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Main Authors: Abd El-Hamid El-Kady R, Waggas D, AkL A
Format: Article
Language:English
Published: Dove Medical Press 2021-10-01
Series:Infection and Drug Resistance
Subjects:
Online Access:https://www.dovepress.com/microbial-repercussion-on-hemodialysis-catheter-related-bloodstream-in-peer-reviewed-fulltext-article-IDR
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spelling doaj-50a5456a598a491c975e10c84bc18b9f2021-10-03T18:58:08ZengDove Medical PressInfection and Drug Resistance1178-69732021-10-01Volume 144067407569358Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective StudyAbd El-Hamid El-Kady RWaggas DAkL ARania Abd El-Hamid El-Kady,1,2 Dania Waggas,2 Ahmed AkL3,4 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Department of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia; 3Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt; 4Department of Internal Medicine/Adult Nephrology, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi ArabiaCorrespondence: Rania Abd El-Hamid El-KadyDepartment of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, 2537, Kingdom of Saudi ArabiaTel +966 569849897Email raniael_kady@yahoo.comBackground: Albeit growing technical advances in the design of hemodialysis catheters, intravascular catheter-related bloodstream infection (CRBSI) still represents an utmost clinical challenge to the health-care workers (HCWs). Data regarding the influence of the culprit organism on the scenario of CRBSI in the literature are extremely lacking. Thereby, this research was carried out.Methods: We undertook a retrospective cohort study over an interval of 2 years, involving patients who underwent regular hemodialysis via catheters in the Renal Dialysis Unit (RDU) of Dr. Soliman Fakeeh Hospital (DSFH), Jeddah, Kingdom of Saudi Arabia (KSA). The study enrolled 139 patients (56.8% females and 43.2% males), with mean age of 60.79 ± 11.45 years.Results: The aggregate rate of CRBSI was 5.1/1000 catheter days. Amongst the 139 study candidates confirmed of having CRBSI, while 69.8% of CRBSIs were ascribed to Gram-positive cocci, about one-third of the infectious episodes were secondary to Gram-negative bacilli. Interestingly, fever was the most common presentation of S. aureus CRBSI compared to CoNS and Gram-negative bacilli CRBSIs (20.9% versus 12.9% versus 6.5%, p= 0.0001), whereas CRBSIs due to CoNS were presented mainly with rigors (19.4%). Of note, CRBSIs caused by Gram-negative bacilli had a tendency to manifest with unusual symptoms such as vomiting or hypotension. Besides, they were more prone to involve hospitalization or ICU admission. In this study, no mortality was attributed to CRBSIs.Conclusion: Our study disclosed that the illicit organism has a repercussion on the clinical presentation as well as the fate of CRBSI among hemodialysis patients. This highlights the worth of identifying the infected cases in a periodic manner, to avoid the occurrence of devastating complications. A large body of work from various hemodialysis centers should take place in the near future so as to provide more insight in this perspective.Keywords: hemodialysis, catheter, ESRD, CRBSI, susceptibilityhttps://www.dovepress.com/microbial-repercussion-on-hemodialysis-catheter-related-bloodstream-in-peer-reviewed-fulltext-article-IDRhemodialysiscatheteresrdcrbsisusceptibility
collection DOAJ
language English
format Article
sources DOAJ
author Abd El-Hamid El-Kady R
Waggas D
AkL A
spellingShingle Abd El-Hamid El-Kady R
Waggas D
AkL A
Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study
Infection and Drug Resistance
hemodialysis
catheter
esrd
crbsi
susceptibility
author_facet Abd El-Hamid El-Kady R
Waggas D
AkL A
author_sort Abd El-Hamid El-Kady R
title Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study
title_short Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study
title_full Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study
title_fullStr Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study
title_full_unstemmed Microbial Repercussion on Hemodialysis Catheter-Related Bloodstream Infection Outcome: A 2-Year Retrospective Study
title_sort microbial repercussion on hemodialysis catheter-related bloodstream infection outcome: a 2-year retrospective study
publisher Dove Medical Press
series Infection and Drug Resistance
issn 1178-6973
publishDate 2021-10-01
description Rania Abd El-Hamid El-Kady,1,2 Dania Waggas,2 Ahmed AkL3,4 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Department of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia; 3Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt; 4Department of Internal Medicine/Adult Nephrology, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi ArabiaCorrespondence: Rania Abd El-Hamid El-KadyDepartment of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, 2537, Kingdom of Saudi ArabiaTel +966 569849897Email raniael_kady@yahoo.comBackground: Albeit growing technical advances in the design of hemodialysis catheters, intravascular catheter-related bloodstream infection (CRBSI) still represents an utmost clinical challenge to the health-care workers (HCWs). Data regarding the influence of the culprit organism on the scenario of CRBSI in the literature are extremely lacking. Thereby, this research was carried out.Methods: We undertook a retrospective cohort study over an interval of 2 years, involving patients who underwent regular hemodialysis via catheters in the Renal Dialysis Unit (RDU) of Dr. Soliman Fakeeh Hospital (DSFH), Jeddah, Kingdom of Saudi Arabia (KSA). The study enrolled 139 patients (56.8% females and 43.2% males), with mean age of 60.79 ± 11.45 years.Results: The aggregate rate of CRBSI was 5.1/1000 catheter days. Amongst the 139 study candidates confirmed of having CRBSI, while 69.8% of CRBSIs were ascribed to Gram-positive cocci, about one-third of the infectious episodes were secondary to Gram-negative bacilli. Interestingly, fever was the most common presentation of S. aureus CRBSI compared to CoNS and Gram-negative bacilli CRBSIs (20.9% versus 12.9% versus 6.5%, p= 0.0001), whereas CRBSIs due to CoNS were presented mainly with rigors (19.4%). Of note, CRBSIs caused by Gram-negative bacilli had a tendency to manifest with unusual symptoms such as vomiting or hypotension. Besides, they were more prone to involve hospitalization or ICU admission. In this study, no mortality was attributed to CRBSIs.Conclusion: Our study disclosed that the illicit organism has a repercussion on the clinical presentation as well as the fate of CRBSI among hemodialysis patients. This highlights the worth of identifying the infected cases in a periodic manner, to avoid the occurrence of devastating complications. A large body of work from various hemodialysis centers should take place in the near future so as to provide more insight in this perspective.Keywords: hemodialysis, catheter, ESRD, CRBSI, susceptibility
topic hemodialysis
catheter
esrd
crbsi
susceptibility
url https://www.dovepress.com/microbial-repercussion-on-hemodialysis-catheter-related-bloodstream-in-peer-reviewed-fulltext-article-IDR
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