Hypothermia and brain inflammation after cardiac arrest

• Main Authors: Pouya Tahsili-Fahadan, Salia Farrokh, Romergryko G Geocadin
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Brain Circulation
• Subjects: Brain injury; cardiac arrest; inflammation; therapeutic hypothermia
• Online Access: http://www.braincirculation.org/article.asp?issn=2394-8108;year=2018;volume=4;issue=1;spage=1;epage=13;aulast=Tahsili-Fahadan
• ISSN: 2394-8108; 2455-4626

The cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying pathophysiology of ischemia-reperfusion brain injury with emphasis on the role of inflammatory mechanisms is reviewed. Potential targets for immunomodulatory treatments and relevant effects of TH are also discussed. Further studies are needed to delineate the complex pathophysiology and interactions among different components of immune response after CA and identify appropriate targets for clinical investigations.