Hypothermia and brain inflammation after cardiac arrest
The cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying path...
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Wolters Kluwer Medknow Publications
2018-01-01
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doaj-50a63748a9fb494a9c48914e64d4ba5c2020-11-24T22:45:53ZengWolters Kluwer Medknow PublicationsBrain Circulation2394-81082455-46262018-01-014111310.4103/bc.BC_4_18Hypothermia and brain inflammation after cardiac arrestPouya Tahsili-FahadanSalia FarrokhRomergryko G GeocadinThe cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying pathophysiology of ischemia-reperfusion brain injury with emphasis on the role of inflammatory mechanisms is reviewed. Potential targets for immunomodulatory treatments and relevant effects of TH are also discussed. Further studies are needed to delineate the complex pathophysiology and interactions among different components of immune response after CA and identify appropriate targets for clinical investigations.http://www.braincirculation.org/article.asp?issn=2394-8108;year=2018;volume=4;issue=1;spage=1;epage=13;aulast=Tahsili-FahadanBrain injurycardiac arrestinflammationtherapeutic hypothermia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pouya Tahsili-Fahadan Salia Farrokh Romergryko G Geocadin |
spellingShingle |
Pouya Tahsili-Fahadan Salia Farrokh Romergryko G Geocadin Hypothermia and brain inflammation after cardiac arrest Brain Circulation Brain injury cardiac arrest inflammation therapeutic hypothermia |
author_facet |
Pouya Tahsili-Fahadan Salia Farrokh Romergryko G Geocadin |
author_sort |
Pouya Tahsili-Fahadan |
title |
Hypothermia and brain inflammation after cardiac arrest |
title_short |
Hypothermia and brain inflammation after cardiac arrest |
title_full |
Hypothermia and brain inflammation after cardiac arrest |
title_fullStr |
Hypothermia and brain inflammation after cardiac arrest |
title_full_unstemmed |
Hypothermia and brain inflammation after cardiac arrest |
title_sort |
hypothermia and brain inflammation after cardiac arrest |
publisher |
Wolters Kluwer Medknow Publications |
series |
Brain Circulation |
issn |
2394-8108 2455-4626 |
publishDate |
2018-01-01 |
description |
The cessation (ischemia) and restoration (reperfusion) of cerebral blood flow after cardiac arrest (CA) induce inflammatory processes that can result in additional brain injury. Therapeutic hypothermia (TH) has been proven as a brain protective strategy after CA. In this article, the underlying pathophysiology of ischemia-reperfusion brain injury with emphasis on the role of inflammatory mechanisms is reviewed. Potential targets for immunomodulatory treatments and relevant effects of TH are also discussed. Further studies are needed to delineate the complex pathophysiology and interactions among different components of immune response after CA and identify appropriate targets for clinical investigations. |
topic |
Brain injury cardiac arrest inflammation therapeutic hypothermia |
url |
http://www.braincirculation.org/article.asp?issn=2394-8108;year=2018;volume=4;issue=1;spage=1;epage=13;aulast=Tahsili-Fahadan |
work_keys_str_mv |
AT pouyatahsilifahadan hypothermiaandbraininflammationaftercardiacarrest AT saliafarrokh hypothermiaandbraininflammationaftercardiacarrest AT romergrykoggeocadin hypothermiaandbraininflammationaftercardiacarrest |
_version_ |
1725687170943942656 |