The changes of subtypes in pediatric diabetes and their clinical and laboratory characteristics over the last 20 years

• Main Authors: Eun Byul Kwon, Hae Sang Lee, Young Seok Shim, Hwal Rim Jeong, Jin Soon Hwang
• Format: Article
• Language: English
• Published: Korean Society of Pediatric Endocrinology 2016-06-01
• Series: Annals of Pediatric Endocrinology & Metabolism
• Subjects: Type 2 diabetes mellitus; Child; Adolescent
• Online Access: http://e-apem.org/upload/pdf/apem-21-81.pdf
• ISSN: 2287-1012; 2287-1292

PurposeWe studied the changes in subtypes of diabetes mellitus (DM) in children and evaluated the characteristics of each group over the past 20 years. In addition, we also examined the correlation between the glycated hemoglobin (HbA1c) values at the time of diagnosis and lipid profiles.MethodsThe patients were divided into 2 groups: there were a total of 190 patients under 20 years of age firstly diagnosed with DM in Ajou University Hospital. The patients in groups I and II were diagnosed from September 1995 to December 2004 and from January 2005 to April 2014, respectively.ResultsThe characteristics were compared between the 2 groups of patients. The result showed an increase in percentage of type 2 diabetes and maturity onset diabetes of the young (MODY) patients between the 2 groups. HbA1c and total cholesterol level had statistical significances to explain increasing the low-density lipoprotein cholesterol level among age, HbA1c, total cholesterol level, and z-scores of weight and body mass index (BMI) in type 2 diabetes. R-square was 0.074. However, z-score of BMI and total cholesterol level, not HbA1c, had statistical significances in type 1 diabetic patients. R-square was 0.323.ConclusionThe increase in the proportions of both type 2 diabetes and MODY in the last 10 years needed to be reminded when diagnosing the subtypes of DM, and the dyslipidemia should be attended more as a common problem of pediatric diabetic patients.