Trachylobane and kaurane diterpenes from Croton floribundus spreng

• Main Authors: Paula Karina S. Uchôa, José Nunes da Silva Jr., Edilberto Rocha Silveira, Mary Anne S. Lima, Raimundo Braz-Filho, Letícia Veras Costa-Lotufo, Ana Jérsia Araújo, Manoel Odorico de Moraes, Claudia do Ó Pessoa
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2013-01-01
• Series: Química Nova
• Subjects: diterpenes; Croton floribundus; Euphorbiaceae
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000600006&lng=en&tlng=en
• ISSN: 1678-7064

A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.