Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions
This 12-months randomized, double-blind and placebo-controlled study aimed at investigating the effects of Lactobacillus casei Zhang (LCZ; 9 log CFU daily) against upper respiratory tract infections (URTI) and gastrointestinal disorders in one hundred thirty-seven (n = 137) healthy adult and elderly...
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doaj-50d455fc6e614a36a11adbc8f2faa0442021-04-30T07:13:16ZengElsevierJournal of Functional Foods1756-46462018-05-0144235245Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actionsYan-Yan Hor0Lee-Ching Lew1Amy Sie-Yik Lau2Jia-Sin Ong3Li-Oon Chuah4Yeong-Yeh Lee5Sy-Bing Choi6Faridah Rashid7Normala Wahid8Zhihong Sun9Lai-Yu Kwok10Heping Zhang11Min-Tze Liong12School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, MalaysiaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, MalaysiaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, MalaysiaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, MalaysiaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, MalaysiaSchool of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, MalaysiaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, MalaysiaSchool of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, MalaysiaCommunity Health Center, Universiti Sains Malaysia, 11800 Penang, MalaysiaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, ChinaKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia 010018, China; Corresponding authors.School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia; Corresponding authors.This 12-months randomized, double-blind and placebo-controlled study aimed at investigating the effects of Lactobacillus casei Zhang (LCZ; 9 log CFU daily) against upper respiratory tract infections (URTI) and gastrointestinal disorders in one hundred thirty-seven (n = 137) healthy adult and elderly Malaysians. LCZ alleviated URTI symptoms in adults, with reduced duration for nasal, pharyngeal, general flu and total respiratory illnesses symptoms compared to the placebo (P < 0.05). These were primarily attributed to activation of T-cells and B-cells and anti-inflammatory properties, as observed via reduced plasma pro-inflammatory cytokines (IL-1), increased anti-inflammatory cytokines (IL-4, IL-10), and upregulated whole blood expressions for CD4, CD8, CD44, CD27 and CXCR5 compared to the placebo (P < 0.05). In elderly subjects, LCZ reduced the duration of nasal symptoms, increased weekly defecation occurrences, and alleviated abnormality of RBC via stabilizing whole blood MCHC and ESR parameters with significant correlations against antioxidative (TBA) and immuno-modulatory (CD44) properties, as compared to the placebo (P < 0.05). With increasing needs for more evidence on strain- and host-dependent efficacy, our current study has illustrated the specific potentials of LCZ against URTI and gastrointestinal health in the adult and elderly populations.http://www.sciencedirect.com/science/article/pii/S1756464618301038Anti-inflammatoryGastrointestinalImmunityLactobacillus casei ZhangUpper respiratory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan-Yan Hor Lee-Ching Lew Amy Sie-Yik Lau Jia-Sin Ong Li-Oon Chuah Yeong-Yeh Lee Sy-Bing Choi Faridah Rashid Normala Wahid Zhihong Sun Lai-Yu Kwok Heping Zhang Min-Tze Liong |
spellingShingle |
Yan-Yan Hor Lee-Ching Lew Amy Sie-Yik Lau Jia-Sin Ong Li-Oon Chuah Yeong-Yeh Lee Sy-Bing Choi Faridah Rashid Normala Wahid Zhihong Sun Lai-Yu Kwok Heping Zhang Min-Tze Liong Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions Journal of Functional Foods Anti-inflammatory Gastrointestinal Immunity Lactobacillus casei Zhang Upper respiratory |
author_facet |
Yan-Yan Hor Lee-Ching Lew Amy Sie-Yik Lau Jia-Sin Ong Li-Oon Chuah Yeong-Yeh Lee Sy-Bing Choi Faridah Rashid Normala Wahid Zhihong Sun Lai-Yu Kwok Heping Zhang Min-Tze Liong |
author_sort |
Yan-Yan Hor |
title |
Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions |
title_short |
Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions |
title_full |
Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions |
title_fullStr |
Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions |
title_full_unstemmed |
Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions |
title_sort |
probiotic lactobacillus casei zhang (lcz) alleviates respiratory, gastrointestinal & rbc abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2018-05-01 |
description |
This 12-months randomized, double-blind and placebo-controlled study aimed at investigating the effects of Lactobacillus casei Zhang (LCZ; 9 log CFU daily) against upper respiratory tract infections (URTI) and gastrointestinal disorders in one hundred thirty-seven (n = 137) healthy adult and elderly Malaysians. LCZ alleviated URTI symptoms in adults, with reduced duration for nasal, pharyngeal, general flu and total respiratory illnesses symptoms compared to the placebo (P < 0.05). These were primarily attributed to activation of T-cells and B-cells and anti-inflammatory properties, as observed via reduced plasma pro-inflammatory cytokines (IL-1), increased anti-inflammatory cytokines (IL-4, IL-10), and upregulated whole blood expressions for CD4, CD8, CD44, CD27 and CXCR5 compared to the placebo (P < 0.05). In elderly subjects, LCZ reduced the duration of nasal symptoms, increased weekly defecation occurrences, and alleviated abnormality of RBC via stabilizing whole blood MCHC and ESR parameters with significant correlations against antioxidative (TBA) and immuno-modulatory (CD44) properties, as compared to the placebo (P < 0.05). With increasing needs for more evidence on strain- and host-dependent efficacy, our current study has illustrated the specific potentials of LCZ against URTI and gastrointestinal health in the adult and elderly populations. |
topic |
Anti-inflammatory Gastrointestinal Immunity Lactobacillus casei Zhang Upper respiratory |
url |
http://www.sciencedirect.com/science/article/pii/S1756464618301038 |
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