The ATP-P2X7 Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation

The ATP-P2X7 Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation

Clostridium difficile infection (CDI) is the leading cause of nosocomial infection in hospitalized patients receiving long-term antibiotic treatment. An excessive host inflammatory response is believed to be the major mechanism underlying the pathogenesis of C. difficile infection, and various proin...

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Bibliographic Details
Main Authors: Ya-Hui Liu, Yung-Chi Chang, Liang-Kuei Chen, Po-An Su, Wen-Chien Ko, Yau-Sheng Tsai, Yi-Hsuan Chen, Hsin-Chih Lai, Cheng-Yeu Wu, Yuan-Pin Hung, Pei-Jane Tsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Clostridium difficile
inflammasome activation
pyroptosis
ATP-P2X7 pathway
MyD88
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00084/full

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00084/full

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