Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome
Dan-hong injection (DHI) is extracted from Salvia miltiorrhiza (SM) and Carthamus tinctorius (CT) and is widely used for the treatment of cardiovascular diseases. Our previous results showed DHI could improve hemorheology in rats. Since complex cellular interactions such as inflammation and oxidativ...
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Format: | Article |
Language: | English |
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Elsevier
2019-10-01
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Series: | Biomedicine & Pharmacotherapy |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332219314106 |
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doaj-50f1556eb1594fbb99e7e8eff8fa5d60 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cong Bi Pan-Lin Li Yan Liao Hong-Yu Rao Pei-Bo Li Jing Yi Wei-Yue Wang Wei-Wei Su |
spellingShingle |
Cong Bi Pan-Lin Li Yan Liao Hong-Yu Rao Pei-Bo Li Jing Yi Wei-Yue Wang Wei-Wei Su Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome Biomedicine & Pharmacotherapy Chinese herbal formula Prescription compatibility connotation Cardiovascular diseases Inflammation Immune response Endothelial function |
author_facet |
Cong Bi Pan-Lin Li Yan Liao Hong-Yu Rao Pei-Bo Li Jing Yi Wei-Yue Wang Wei-Wei Su |
author_sort |
Cong Bi |
title |
Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome |
title_short |
Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome |
title_full |
Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome |
title_fullStr |
Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome |
title_full_unstemmed |
Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome |
title_sort |
pharmacodynamic effects of dan-hong injection in rats with blood stasis syndrome |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-10-01 |
description |
Dan-hong injection (DHI) is extracted from Salvia miltiorrhiza (SM) and Carthamus tinctorius (CT) and is widely used for the treatment of cardiovascular diseases. Our previous results showed DHI could improve hemorheology in rats. Since complex cellular interactions such as inflammation and oxidative stress are believed to be implicated in the pathogenesis of cardiovascular events, investigation of such pathological factors will contribute substantially to the understanding of the features and mechanisms of DHI. Therefore, in this study we used a rat model of blood stasis to explore the overall effects of DHI by detecting twenty three indexes, which were related to inflammation, immune response, vascular endothelial function, myocardial energy metabolism, oxidative stress, platelet aggregation, liver and renal function. Meanwhile, the interaction between SM and CT was discussed by comparing the effects of each single herb. DHI could significantly decrease the serum contents of IL-1β, TNF-α, IL-6, IL-8, IgM, IgG, IgA, MPO, hs-CRP, MDA, LDH, CK-MB, PAF, ALP and Cr, while elevate NO, SOD, TP and UA levels, indicating that DHI could inhibit inflammation and platelet aggregation, thereby relieving immune response and peroxidation, protecting vascular endothelial and organ function, and then prevent and treat cardiovascular diseases. In terms of compatibility, SM and CT showed complementary effects on markers of inflammatory and oxidative status, vascular endothelial damage and myocardial energy metabolism. On the other hand, they counteracted each other and SM reduced the side effects of creatinine caused by CT. This study contributes to comprehensively understand the pharmacodynamics effects and mechanism of DHI. |
topic |
Chinese herbal formula Prescription compatibility connotation Cardiovascular diseases Inflammation Immune response Endothelial function |
url |
http://www.sciencedirect.com/science/article/pii/S0753332219314106 |
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AT congbi pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT panlinli pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT yanliao pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT hongyurao pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT peiboli pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT jingyi pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT weiyuewang pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome AT weiweisu pharmacodynamiceffectsofdanhonginjectioninratswithbloodstasissyndrome |
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spelling |
doaj-50f1556eb1594fbb99e7e8eff8fa5d602021-05-21T04:17:24ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-10-01118Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndromeCong Bi0Pan-Lin Li1Yan Liao2Hong-Yu Rao3Pei-Bo Li4Jing Yi5Wei-Yue Wang6Wei-Wei Su7Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaGuangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaGuangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaGuangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaGuangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaGuangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaGuangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaCorresponding author.; Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou 510275, ChinaDan-hong injection (DHI) is extracted from Salvia miltiorrhiza (SM) and Carthamus tinctorius (CT) and is widely used for the treatment of cardiovascular diseases. Our previous results showed DHI could improve hemorheology in rats. Since complex cellular interactions such as inflammation and oxidative stress are believed to be implicated in the pathogenesis of cardiovascular events, investigation of such pathological factors will contribute substantially to the understanding of the features and mechanisms of DHI. Therefore, in this study we used a rat model of blood stasis to explore the overall effects of DHI by detecting twenty three indexes, which were related to inflammation, immune response, vascular endothelial function, myocardial energy metabolism, oxidative stress, platelet aggregation, liver and renal function. Meanwhile, the interaction between SM and CT was discussed by comparing the effects of each single herb. DHI could significantly decrease the serum contents of IL-1β, TNF-α, IL-6, IL-8, IgM, IgG, IgA, MPO, hs-CRP, MDA, LDH, CK-MB, PAF, ALP and Cr, while elevate NO, SOD, TP and UA levels, indicating that DHI could inhibit inflammation and platelet aggregation, thereby relieving immune response and peroxidation, protecting vascular endothelial and organ function, and then prevent and treat cardiovascular diseases. In terms of compatibility, SM and CT showed complementary effects on markers of inflammatory and oxidative status, vascular endothelial damage and myocardial energy metabolism. On the other hand, they counteracted each other and SM reduced the side effects of creatinine caused by CT. This study contributes to comprehensively understand the pharmacodynamics effects and mechanism of DHI.http://www.sciencedirect.com/science/article/pii/S0753332219314106Chinese herbal formulaPrescription compatibility connotationCardiovascular diseasesInflammationImmune responseEndothelial function |