Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis

Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis

Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of...

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Main Authors: Stephan Klopries, Kenny Bravo-Rodriguez, Kyra R.M. Koopmans, Uschi Sundermann, Samir Yahiaoui, Julia Arens, Susanna Kushnir, Elsa Sanchez-Garcia, Frank Schulz
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340915002462
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spelling doaj-50f2172f437340e9a54167062ede04352020-11-24T21:53:26ZengElsevierData in Brief2352-34092015-12-015C52853610.1016/j.dib.2015.09.052Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesisStephan Klopries0Kenny Bravo-Rodriguez1Kyra R.M. Koopmans2Uschi Sundermann3Samir Yahiaoui4Julia Arens5Susanna Kushnir6Elsa Sanchez-Garcia7Frank Schulz8Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, GermanyMax-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, GermanyFakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, GermanyDr. Fooke-Achterrath Laboratorien GmbH, Habichtweg 16, 41468 Neuss, GermanyUniversité de Caen Basse-Normandie, Centre d’Etudes et de Recherche sur le Médicament de Normandie, F-14032 Caen, FranceFakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, GermanyFakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, GermanyMax-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, GermanyFakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, GermanyEnzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented.http://www.sciencedirect.com/science/article/pii/S2352340915002462
collection DOAJ
language English
format Article
sources DOAJ
author Stephan Klopries
Kenny Bravo-Rodriguez
Kyra R.M. Koopmans
Uschi Sundermann
Samir Yahiaoui
Julia Arens
Susanna Kushnir
Elsa Sanchez-Garcia
Frank Schulz
spellingShingle Stephan Klopries
Kenny Bravo-Rodriguez
Kyra R.M. Koopmans
Uschi Sundermann
Samir Yahiaoui
Julia Arens
Susanna Kushnir
Elsa Sanchez-Garcia
Frank Schulz
Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
Data in Brief
author_facet Stephan Klopries
Kenny Bravo-Rodriguez
Kyra R.M. Koopmans
Uschi Sundermann
Samir Yahiaoui
Julia Arens
Susanna Kushnir
Elsa Sanchez-Garcia
Frank Schulz
author_sort Stephan Klopries
title Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_short Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_full Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_fullStr Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_full_unstemmed Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_sort data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2015-12-01
description Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented.
url http://www.sciencedirect.com/science/article/pii/S2352340915002462
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