Effects of early statins combined with intravenous thrombolysis on nerve function and cytokine secretion in patients with acute cerebral infarction

• Main Author: Xin-Wei Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-11-01
• Series: Journal of Hainan Medical University
• Subjects: Acute cerebral infarction; Statins; Nerve function; Adipocytokines; Oxidative stress
• Online Access: http://www.hnykdxxb.com/PDF/201722/05.pdf

Objective: To investigate the effects of early statins combined with intravenous thrombolysis on nerve function and cytokine secretion in patients with acute cerebral infarction. Methods: A total of 210 patients with acute cerebral infarction who were treated in the hospital between September 2015 and March 2017 were divided into control group (n=105) and statin group (n=105) by random number table. Control group received intravenous thrombolysis therapy, and statin group received early statins combined with intravenous thrombolysis therapy. The differences in serum levels of nerve function indicators, adipocytokines and oxidative stress indexes were compared between the two groups immediately after admission and after treatment. Results: Before treatment, the differences in serum levels of nerve function indexes, adipocytokines and oxidative stress indexes were not statistically significant between the two groups. After treatment, serum nerve function index S100B level of statin group was lower than that of control group whereas BDNF level was higher than that of control group; serum adipocytokine APN level was higher than that of control group while Resistin and Visfatin levels were lower than those of control group; serum oxidative stress indexes AOPPs and LHP levels were lower than those of control group whereas SOD and T-AOC levels were higher than those of control group. Conclusion: Early statins combined with intravenous thrombolysis can effectively improve the nerve function of patients with acute cerebral infarction, coordinate the secretion of a variety of cytokines and inhibit the activation of oxidative stress response.