Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study.
OBJECTIVE:To evaluate improvement in survival of lymphoma patients from 1990 to 2014, stratified by age, sex and race using Surveillance Epidemiology and End-Result Survey Program (SEER) data. STUDY DESIGN AND SETTING:We identified 113,788 incident lymphoma cases from nine SEER cancer registries wer...
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doaj-511010d4a31a4f21a83483403050cb3b2020-11-24T21:55:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e019974510.1371/journal.pone.0199745Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study.Fahad MukhtarPaolo BoffettaBashir DaboJong Y ParkChi T D TranThuan V TranHuong Thi-Thanh TranMadison WhitneyHarvey A RischLinh C LeWei ZhengXiao-Ou ShuHung N LuuOBJECTIVE:To evaluate improvement in survival of lymphoma patients from 1990 to 2014, stratified by age, sex and race using Surveillance Epidemiology and End-Result Survey Program (SEER) data. STUDY DESIGN AND SETTING:We identified 113,788 incident lymphoma cases from nine SEER cancer registries were followed up for cause-specific mortality from lymphoma. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and their respective 95% confidence interval (CIs) for various time periods within groups stratified by race, age and sex. RESULTS:Five-year survival for Hodgkin's lymphoma (HL) was 89% for patients 20-49 years of age. For this age group, compared to 1990-1994, survival significantly improved in 2000-2004 (HR = 0.65; 95% CI: 0.54-0.78), 2005-2009 (HR = 0.46, 95% CI: 0.38-0.57) and 2010-2014 (HR = 0.29, 95% CI: 0.20-0.41). Hodgkin's lymphoma patients aged 75-85 years had 5-year survival of 37% and in these patients, compared to 1990-1994, survival only improved from 2005 onward (HR = 0.67, 95% CI: 0.50-0.90). In patients with non-Hodgkin's Lymphoma (NHL), all age groups showed survival improvements between 1990-1994 period and 2010-2014 period. Improvements in HL and NHL survival were seen for all race categories and both genders. CONCLUSION:Survival among US lymphoma patients has improved substantially between 1990-1994 period and 2010-2014 period, though disease-specific mortality was still higher in older age groups.http://europepmc.org/articles/PMC6040734?pdf=render |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fahad Mukhtar Paolo Boffetta Bashir Dabo Jong Y Park Chi T D Tran Thuan V Tran Huong Thi-Thanh Tran Madison Whitney Harvey A Risch Linh C Le Wei Zheng Xiao-Ou Shu Hung N Luu |
spellingShingle |
Fahad Mukhtar Paolo Boffetta Bashir Dabo Jong Y Park Chi T D Tran Thuan V Tran Huong Thi-Thanh Tran Madison Whitney Harvey A Risch Linh C Le Wei Zheng Xiao-Ou Shu Hung N Luu Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. PLoS ONE |
author_facet |
Fahad Mukhtar Paolo Boffetta Bashir Dabo Jong Y Park Chi T D Tran Thuan V Tran Huong Thi-Thanh Tran Madison Whitney Harvey A Risch Linh C Le Wei Zheng Xiao-Ou Shu Hung N Luu |
author_sort |
Fahad Mukhtar |
title |
Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. |
title_short |
Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. |
title_full |
Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. |
title_fullStr |
Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. |
title_full_unstemmed |
Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. |
title_sort |
disparities by race, age, and sex in the improvement of survival for lymphoma: findings from a population-based study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
OBJECTIVE:To evaluate improvement in survival of lymphoma patients from 1990 to 2014, stratified by age, sex and race using Surveillance Epidemiology and End-Result Survey Program (SEER) data. STUDY DESIGN AND SETTING:We identified 113,788 incident lymphoma cases from nine SEER cancer registries were followed up for cause-specific mortality from lymphoma. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and their respective 95% confidence interval (CIs) for various time periods within groups stratified by race, age and sex. RESULTS:Five-year survival for Hodgkin's lymphoma (HL) was 89% for patients 20-49 years of age. For this age group, compared to 1990-1994, survival significantly improved in 2000-2004 (HR = 0.65; 95% CI: 0.54-0.78), 2005-2009 (HR = 0.46, 95% CI: 0.38-0.57) and 2010-2014 (HR = 0.29, 95% CI: 0.20-0.41). Hodgkin's lymphoma patients aged 75-85 years had 5-year survival of 37% and in these patients, compared to 1990-1994, survival only improved from 2005 onward (HR = 0.67, 95% CI: 0.50-0.90). In patients with non-Hodgkin's Lymphoma (NHL), all age groups showed survival improvements between 1990-1994 period and 2010-2014 period. Improvements in HL and NHL survival were seen for all race categories and both genders. CONCLUSION:Survival among US lymphoma patients has improved substantially between 1990-1994 period and 2010-2014 period, though disease-specific mortality was still higher in older age groups. |
url |
http://europepmc.org/articles/PMC6040734?pdf=render |
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