Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat

Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat

Abstract Background Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucid...

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Bibliographic Details
Main Authors: Ka-Yeon Lee, Jae-Hyun Kim, Eun-Young Kim, Mijung Yeom, Hyuk-Sang Jung, Youngjoo Sohn
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Cnidii Rhizoma
Osteoclast, NFATc1, c-Fos
Ovariectomized-rat
Online Access:http://link.springer.com/article/10.1186/s12906-019-2611-8

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