Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study
Aims: Freezing of gait is a disabling symptom in advanced Parkinson's disease. Positive effects have been suggested with MAO-B inhibitors. We report on an open label clinical study on the efficacy of rasagiline as add-on therapy on freezing of gait and quality of life in patients with Parkinson...
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2016-12-01
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doaj-511cfe65c72d4f668bf47a345f017e922020-11-25T01:20:26ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212016-12-01160454955210.5507/bp.2016.023bio-201604-0015Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter studyFrantišek Cibulcik0Jan Benetin1Egon Kurca2Milan Grofik3Miloslav Dvorak4Denis Richter5Vladimir Donath6Jan Kothaj7Michal Minar8Peter Valkovic9Department of Neurology, Faculty of Medicine, Slovak Medical University in Bratislava and University Hospital Bratislava, Slovak RepublicDepartment of Neurology, Faculty of Medicine, Slovak Medical University in Bratislava and University Hospital Bratislava, Slovak RepublicDepartment of Neurology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin and University Hospital Martin, Slovak RepublicDepartment of Neurology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin and University Hospital Martin, Slovak RepublicDepartment of Neurology, Hospital Spisska Nova Ves, Slovak RepublicDepartment of Neurology, University Hospital Bratislava, Slovak RepublicDepartment of Neurology, Slovak Health University, Roosevelt Hospital Banska Bystrica, Slovak RepublicDepartment of Neurology, Slovak Health University, Roosevelt Hospital Banska Bystrica, Slovak RepublicSecond Department of Neurology, Faculty of Medicine, Comenius University in Bratislava, Slovak RepublicSecond Department of Neurology, Faculty of Medicine, Comenius University in Bratislava, Slovak RepublicAims: Freezing of gait is a disabling symptom in advanced Parkinson's disease. Positive effects have been suggested with MAO-B inhibitors. We report on an open label clinical study on the efficacy of rasagiline as add-on therapy on freezing of gait and quality of life in patients with Parkinson's disease. Methods: Forty two patients with freezing of gait were treated with 1 mg rasagiline daily as an add-on therapy. Patients were assessed at baseline and after 1, 2 and 3 months of treatment. Freezing of gait severity was assessed using the Freezing of Gait Questionnaire, motor impairment by the modified MDS UPDRS part III, and quality of life using the PDQ-39 questionnaire. Results: Patients treated with rasagiline had a statistically significant decrease in FoG-Q score and modified MDS UPDRS score after 1, 2 and 3 months of therapy. A moderately strong (r = 0.686, P = 0.002) correlation between the effects on mobility and freezing of gait was found. We also observed a statistically significant improvement in global QoL and in the subscales mobility, ADL, stigma and bodily discomfort in patients after 3 months of rasagiline therapy. A significant correlation (r = 0.570, P = 0.02) between baseline FoG-Q score and the baseline score for the PDQ Mobility subscale was found. Conclusion: In our study rasagiline as add-on antiparkinsonian therapy significantly improved mobility, freezing of gait and quality of life. The positive effect on freezing of gait appears to be related to improvement of mobility.https://biomed.papers.upol.cz/artkey/bio-201604-0015_Effects_of_rasagiline_on_freezing_of_gait_in_Parkinson_s_disease_-_an_open-label_multicenter_study.phpparkinson's diseasefreezing of gaitrasagiline |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
František Cibulcik Jan Benetin Egon Kurca Milan Grofik Miloslav Dvorak Denis Richter Vladimir Donath Jan Kothaj Michal Minar Peter Valkovic |
spellingShingle |
František Cibulcik Jan Benetin Egon Kurca Milan Grofik Miloslav Dvorak Denis Richter Vladimir Donath Jan Kothaj Michal Minar Peter Valkovic Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study Biomedical Papers parkinson's disease freezing of gait rasagiline |
author_facet |
František Cibulcik Jan Benetin Egon Kurca Milan Grofik Miloslav Dvorak Denis Richter Vladimir Donath Jan Kothaj Michal Minar Peter Valkovic |
author_sort |
František Cibulcik |
title |
Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study |
title_short |
Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study |
title_full |
Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study |
title_fullStr |
Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study |
title_full_unstemmed |
Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study |
title_sort |
effects of rasagiline on freezing of gait in parkinson's disease - an open-label, multicenter study |
publisher |
Palacký University Olomouc, Faculty of Medicine and Dentistry |
series |
Biomedical Papers |
issn |
1213-8118 1804-7521 |
publishDate |
2016-12-01 |
description |
Aims: Freezing of gait is a disabling symptom in advanced Parkinson's disease. Positive effects have been suggested with MAO-B inhibitors. We report on an open label clinical study on the efficacy of rasagiline as add-on therapy on freezing of gait and quality of life in patients with Parkinson's disease. Methods: Forty two patients with freezing of gait were treated with 1 mg rasagiline daily as an add-on therapy. Patients were assessed at baseline and after 1, 2 and 3 months of treatment. Freezing of gait severity was assessed using the Freezing of Gait Questionnaire, motor impairment by the modified MDS UPDRS part III, and quality of life using the PDQ-39 questionnaire. Results: Patients treated with rasagiline had a statistically significant decrease in FoG-Q score and modified MDS UPDRS score after 1, 2 and 3 months of therapy. A moderately strong (r = 0.686, P = 0.002) correlation between the effects on mobility and freezing of gait was found. We also observed a statistically significant improvement in global QoL and in the subscales mobility, ADL, stigma and bodily discomfort in patients after 3 months of rasagiline therapy. A significant correlation (r = 0.570, P = 0.02) between baseline FoG-Q score and the baseline score for the PDQ Mobility subscale was found. Conclusion: In our study rasagiline as add-on antiparkinsonian therapy significantly improved mobility, freezing of gait and quality of life. The positive effect on freezing of gait appears to be related to improvement of mobility. |
topic |
parkinson's disease freezing of gait rasagiline |
url |
https://biomed.papers.upol.cz/artkey/bio-201604-0015_Effects_of_rasagiline_on_freezing_of_gait_in_Parkinson_s_disease_-_an_open-label_multicenter_study.php |
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