Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR tech...

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Bibliographic Details
Main Authors: Dehai Li, Tianjiao Zhu, Qianqun Gu, Guangwei Wu, Aiqun Lin
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Marine Drugs
Subjects:
chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp.
Online Access:http://www.mdpi.com/1660-3397/11/4/1399
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spelling doaj-512ae40f11644c3ba09ac808f4a4761b2020-11-24T23:45:05ZengMDPI AGMarine Drugs1660-33972013-04-011141399140810.3390/md11041399Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1Dehai LiTianjiao ZhuQianqun GuGuangwei WuAiqun LinA new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.http://www.mdpi.com/1660-3397/11/4/1399chlorinated eremophilane sesquiterpeneAntarctic deep-sea derived fungusPenicillium sp.
collection DOAJ
language English
format Article
sources DOAJ
author Dehai Li
Tianjiao Zhu
Qianqun Gu
Guangwei Wu
Aiqun Lin
spellingShingle Dehai Li
Tianjiao Zhu
Qianqun Gu
Guangwei Wu
Aiqun Lin
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
Marine Drugs
chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp.
author_facet Dehai Li
Tianjiao Zhu
Qianqun Gu
Guangwei Wu
Aiqun Lin
author_sort Dehai Li
title Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_short Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_fullStr Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full_unstemmed Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_sort four new chloro-eremophilane sesquiterpenes from an antarctic deep-sea derived fungus, penicillium sp. pr19n-1
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2013-04-01
description A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.
topic chlorinated eremophilane sesquiterpene
Antarctic deep-sea derived fungus
Penicillium sp.
url http://www.mdpi.com/1660-3397/11/4/1399
work_keys_str_mv AT dehaili fournewchloroeremophilanesesquiterpenesfromanantarcticdeepseaderivedfunguspenicilliumsppr19n1
AT tianjiaozhu fournewchloroeremophilanesesquiterpenesfromanantarcticdeepseaderivedfunguspenicilliumsppr19n1
AT qianqungu fournewchloroeremophilanesesquiterpenesfromanantarcticdeepseaderivedfunguspenicilliumsppr19n1
AT guangweiwu fournewchloroeremophilanesesquiterpenesfromanantarcticdeepseaderivedfunguspenicilliumsppr19n1
AT aiqunlin fournewchloroeremophilanesesquiterpenesfromanantarcticdeepseaderivedfunguspenicilliumsppr19n1
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