Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR tech...
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doaj-512ae40f11644c3ba09ac808f4a4761b2020-11-24T23:45:05ZengMDPI AGMarine Drugs1660-33972013-04-011141399140810.3390/md11041399Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1Dehai LiTianjiao ZhuQianqun GuGuangwei WuAiqun LinA new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.http://www.mdpi.com/1660-3397/11/4/1399chlorinated eremophilane sesquiterpeneAntarctic deep-sea derived fungusPenicillium sp. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dehai Li Tianjiao Zhu Qianqun Gu Guangwei Wu Aiqun Lin |
spellingShingle |
Dehai Li Tianjiao Zhu Qianqun Gu Guangwei Wu Aiqun Lin Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 Marine Drugs chlorinated eremophilane sesquiterpene Antarctic deep-sea derived fungus Penicillium sp. |
author_facet |
Dehai Li Tianjiao Zhu Qianqun Gu Guangwei Wu Aiqun Lin |
author_sort |
Dehai Li |
title |
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 |
title_short |
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 |
title_full |
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 |
title_fullStr |
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 |
title_full_unstemmed |
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 |
title_sort |
four new chloro-eremophilane sesquiterpenes from an antarctic deep-sea derived fungus, penicillium sp. pr19n-1 |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2013-04-01 |
description |
A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. |
topic |
chlorinated eremophilane sesquiterpene Antarctic deep-sea derived fungus Penicillium sp. |
url |
http://www.mdpi.com/1660-3397/11/4/1399 |
work_keys_str_mv |
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