Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice

Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice

TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppressor gene in B lymphocytes. Specific deletion of TRAF3 from B lymphocytes leads to spontaneous development of marginal zone lymphomas (MZL) or B1 lymphomas in mice. To identify novel oncogenes and tumor suppress...

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Main Authors: Ping Xie, Carissa R. Moore, Mavis R. Swerdel, Ronald P. Hart
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Genomics Data
Subjects:
MCC
TRAF3
B lymphoma
multiple myeloma
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596014001068
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spelling doaj-512afdf0aa0d470c9f003ac4be63793c2020-11-25T02:56:50ZengElsevierGenomics Data2213-59602014-12-012C38638810.1016/j.gdata.2014.10.017Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient micePing Xie0Carissa R. Moore1Mavis R. Swerdel2Ronald P. Hart3Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United StatesDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United StatesDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United StatesDepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United StatesTRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppressor gene in B lymphocytes. Specific deletion of TRAF3 from B lymphocytes leads to spontaneous development of marginal zone lymphomas (MZL) or B1 lymphomas in mice. To identify novel oncogenes and tumor suppressive genes involved in malignant transformation of TRAF3-deficient B cells, we performed a microarray analysis to identify genes differentially expressed in TRAF3−/− mouse splenic B lymphomas. We have identified 160 up-regulated genes and 244 down-regulated genes in TRAF3−/−B lymphomas as compared to littermate control splenocytes. Here we describe the samples, quality control assessment, as well as the data analysis methods in detail for the transcriptomic profiling study. Data are archived at NIH GEO with accession number GSE48818.http://www.sciencedirect.com/science/article/pii/S2213596014001068MCCTRAF3B lymphomamultiple myeloma
collection DOAJ
language English
format Article
sources DOAJ
author Ping Xie
Carissa R. Moore
Mavis R. Swerdel
Ronald P. Hart
spellingShingle Ping Xie
Carissa R. Moore
Mavis R. Swerdel
Ronald P. Hart
Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice
Genomics Data
MCC
TRAF3
B lymphoma
multiple myeloma
author_facet Ping Xie
Carissa R. Moore
Mavis R. Swerdel
Ronald P. Hart
author_sort Ping Xie
title Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice
title_short Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice
title_full Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice
title_fullStr Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice
title_full_unstemmed Transcriptomic profiling of splenic B lymphomas spontaneously developed in B cell-specific TRAF3-deficient mice
title_sort transcriptomic profiling of splenic b lymphomas spontaneously developed in b cell-specific traf3-deficient mice
publisher Elsevier
series Genomics Data
issn 2213-5960
publishDate 2014-12-01
description TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppressor gene in B lymphocytes. Specific deletion of TRAF3 from B lymphocytes leads to spontaneous development of marginal zone lymphomas (MZL) or B1 lymphomas in mice. To identify novel oncogenes and tumor suppressive genes involved in malignant transformation of TRAF3-deficient B cells, we performed a microarray analysis to identify genes differentially expressed in TRAF3−/− mouse splenic B lymphomas. We have identified 160 up-regulated genes and 244 down-regulated genes in TRAF3−/−B lymphomas as compared to littermate control splenocytes. Here we describe the samples, quality control assessment, as well as the data analysis methods in detail for the transcriptomic profiling study. Data are archived at NIH GEO with accession number GSE48818.
topic MCC
TRAF3
B lymphoma
multiple myeloma
url http://www.sciencedirect.com/science/article/pii/S2213596014001068
work_keys_str_mv AT pingxie transcriptomicprofilingofsplenicblymphomasspontaneouslydevelopedinbcellspecifictraf3deficientmice
AT carissarmoore transcriptomicprofilingofsplenicblymphomasspontaneouslydevelopedinbcellspecifictraf3deficientmice
AT mavisrswerdel transcriptomicprofilingofsplenicblymphomasspontaneouslydevelopedinbcellspecifictraf3deficientmice
AT ronaldphart transcriptomicprofilingofsplenicblymphomasspontaneouslydevelopedinbcellspecifictraf3deficientmice
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