<i>In vivo</i> Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice

• Main Authors: Khairul Islam, Shaikh M Mohsin Ali, Mele Jesmin, Jahan Ara Khanam
• Format: Article
• Language: English
• Published: China Anti-Cancer Association 2012-12-01
• Series: Cancer Biology & Medicine
• Subjects: anticancer activities; EAC cell; benzophenone semicarbazone
• Online Access: http://www.cancerbiomed.org/index.php/cocr/article/view/372

<b>Objective</b> Benzophenone semicarbazone (BSC) was synthesized and characterized to identify compounds with anticancer activities.<br><b>Methods</b> Anticancer activities were studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological parameters, such as red blood cells, white blood cells, and hemoglobin content, were also measured.<br><b>Results</b> The results showed that BSC has a positive effect against EAC cells. An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin.<br><b>Conclusions</b> The BSC compound can be considered as a potent anticancer agent.