Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial

Abstract Background Since the Aedes aegypti mosquitoes that transmit dengue virus can breed in clean water, WHO-endorsed vector control strategies place sachets of organophosphate pesticide, temephos (Abate), in household water storage containers. These and other pesticide-dependent approaches have...

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Main Authors: Neil Andersson, Jorge Arostegui, Elizabeth Nava-Aguilera, Eva Harris, Robert J Ledogar
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Public Health
Online Access:http://link.springer.com/article/10.1186/s12889-017-4289-5
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spelling doaj-512bbf6cd9674723b78ff0506898e7362020-11-24T22:20:15ZengBMCBMC Public Health1471-24582017-05-0117S1112010.1186/s12889-017-4289-5Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trialNeil Andersson0Jorge Arostegui1Elizabeth Nava-Aguilera2Eva Harris3Robert J Ledogar4Centro de Investigación de Enfermedades Tropicales (CIET), Universidad Autónoma de GuerreroCIETCentro de Investigación de Enfermedades Tropicales (CIET), Universidad Autónoma de GuerreroDivision of Infectious Diseases and Vaccinology, School of Public Health, University of CaliforniaCIET internationalAbstract Background Since the Aedes aegypti mosquitoes that transmit dengue virus can breed in clean water, WHO-endorsed vector control strategies place sachets of organophosphate pesticide, temephos (Abate), in household water storage containers. These and other pesticide-dependent approaches have failed to curb the spread of dengue and multiple dengue virus serotypes continue to spread throughout tropical and subtropical regions worldwide. A feasibility study in Managua, Nicaragua, generated instruments, intervention protocols, training schedules and impact assessment tools for a cluster randomised controlled trial of community-based approaches to vector control comprising an alternative strategy for dengue prevention and control in Nicaragua and Mexico. Methods/Design The Camino Verde (Green Way) is a pragmatic parallel group trial of pesticide-free dengue vector control, adding effectiveness to the standard government dengue control. A random sample from the most recent census in three coastal regions of Guerrero state in Mexico will generate 90 study clusters and the equivalent sampling frame in Managua, Nicaragua will generate 60 clusters, making a total of 150 clusters each of 137–140 households. After a baseline study, computer-driven randomisation will allocate to intervention one half of the sites, stratified by country, evidence of recent dengue virus infection in children aged 3–9 years and, in Nicaragua, level of community organisation. Following a common evidence-based education protocol, each cluster will develop and implement its own collective interventions including house-to-house visits, school-based programmes and inter-community visits. After 18 months, a follow-up study will compare dengue history, serological evidence of recent dengue virus infection (via measurement of anti-dengue virus antibodies in saliva samples) and entomological indices between intervention and control sites. Discussion Our hypothesis is that informed community mobilisation adds effectiveness in controlling dengue. Trial registration ISRCTN27581154 .http://link.springer.com/article/10.1186/s12889-017-4289-5
collection DOAJ
language English
format Article
sources DOAJ
author Neil Andersson
Jorge Arostegui
Elizabeth Nava-Aguilera
Eva Harris
Robert J Ledogar
spellingShingle Neil Andersson
Jorge Arostegui
Elizabeth Nava-Aguilera
Eva Harris
Robert J Ledogar
Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial
BMC Public Health
author_facet Neil Andersson
Jorge Arostegui
Elizabeth Nava-Aguilera
Eva Harris
Robert J Ledogar
author_sort Neil Andersson
title Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial
title_short Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial
title_full Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial
title_fullStr Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial
title_full_unstemmed Camino Verde (The Green Way): evidence-based community mobilisation for dengue control in Nicaragua and Mexico: feasibility study and study protocol for a randomised controlled trial
title_sort camino verde (the green way): evidence-based community mobilisation for dengue control in nicaragua and mexico: feasibility study and study protocol for a randomised controlled trial
publisher BMC
series BMC Public Health
issn 1471-2458
publishDate 2017-05-01
description Abstract Background Since the Aedes aegypti mosquitoes that transmit dengue virus can breed in clean water, WHO-endorsed vector control strategies place sachets of organophosphate pesticide, temephos (Abate), in household water storage containers. These and other pesticide-dependent approaches have failed to curb the spread of dengue and multiple dengue virus serotypes continue to spread throughout tropical and subtropical regions worldwide. A feasibility study in Managua, Nicaragua, generated instruments, intervention protocols, training schedules and impact assessment tools for a cluster randomised controlled trial of community-based approaches to vector control comprising an alternative strategy for dengue prevention and control in Nicaragua and Mexico. Methods/Design The Camino Verde (Green Way) is a pragmatic parallel group trial of pesticide-free dengue vector control, adding effectiveness to the standard government dengue control. A random sample from the most recent census in three coastal regions of Guerrero state in Mexico will generate 90 study clusters and the equivalent sampling frame in Managua, Nicaragua will generate 60 clusters, making a total of 150 clusters each of 137–140 households. After a baseline study, computer-driven randomisation will allocate to intervention one half of the sites, stratified by country, evidence of recent dengue virus infection in children aged 3–9 years and, in Nicaragua, level of community organisation. Following a common evidence-based education protocol, each cluster will develop and implement its own collective interventions including house-to-house visits, school-based programmes and inter-community visits. After 18 months, a follow-up study will compare dengue history, serological evidence of recent dengue virus infection (via measurement of anti-dengue virus antibodies in saliva samples) and entomological indices between intervention and control sites. Discussion Our hypothesis is that informed community mobilisation adds effectiveness in controlling dengue. Trial registration ISRCTN27581154 .
url http://link.springer.com/article/10.1186/s12889-017-4289-5
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