Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients
In spite of the effective implementation of screening programs, uterine cervical carcinoma (UCC) remains one of the major causes of cancer death among women around the world. The aim of this study was to investigate the prognostic value of serum human epididymis protein 4 (HE4) in UCC. Pre-treatment...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-09-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.584022/full |
id |
doaj-5130fb4b05f14aa4be9ad2d0f243407e |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eliana Bignotti Eliana Bignotti Laura Zanotti Laura Zanotti Paola Todeschini Valentina Zizioli Chiara Romani Davide Capoferri Germana Tognon Enrico Sartori Enrico Sartori Stefano Calza Stefano Calza Stefano Calza Franco Odicino Franco Odicino Franco Odicino Antonella Ravaggi Antonella Ravaggi Antonella Ravaggi |
spellingShingle |
Eliana Bignotti Eliana Bignotti Laura Zanotti Laura Zanotti Paola Todeschini Valentina Zizioli Chiara Romani Davide Capoferri Germana Tognon Enrico Sartori Enrico Sartori Stefano Calza Stefano Calza Stefano Calza Franco Odicino Franco Odicino Franco Odicino Antonella Ravaggi Antonella Ravaggi Antonella Ravaggi Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients Frontiers in Oncology uterine cervical carcinoma HE4 biomarker prognosis serum |
author_facet |
Eliana Bignotti Eliana Bignotti Laura Zanotti Laura Zanotti Paola Todeschini Valentina Zizioli Chiara Romani Davide Capoferri Germana Tognon Enrico Sartori Enrico Sartori Stefano Calza Stefano Calza Stefano Calza Franco Odicino Franco Odicino Franco Odicino Antonella Ravaggi Antonella Ravaggi Antonella Ravaggi |
author_sort |
Eliana Bignotti |
title |
Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients |
title_short |
Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients |
title_full |
Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients |
title_fullStr |
Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients |
title_full_unstemmed |
Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients |
title_sort |
pre-treatment serum he4 level as a novel independent prognostic biomarker for uterine cervical carcinoma patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-09-01 |
description |
In spite of the effective implementation of screening programs, uterine cervical carcinoma (UCC) remains one of the major causes of cancer death among women around the world. The aim of this study was to investigate the prognostic value of serum human epididymis protein 4 (HE4) in UCC. Pre-treatment serum samples from 109 UCC patients and 99 healthy women were analyzed for HE4 levels by a quantitative chemiluminescent microparticle immunoassay on the automated ARCHITECT instrument. HE4 serum (sHE4) levels were significantly higher in UCC patients, regardless of tumor stage, compared with healthy controls. Elevated sHE4 levels were significantly associated with advanced FIGO stage and absence of disease-free interval after treatment. In univariable analysis, higher sHE4 levels were significantly correlated with shorter overall survival and progression-free survival. In multivariable analysis, sHE4 retained its significance as independent adverse prognostic factor for both survival endpoints. This study indicates that sHE4 is associated with a more aggressive tumor phenotype and a worse patient's prognosis. These results suggest the potential role of sHE4 as a novel prognostic marker and as an indicator of high-risk UCC patients for a tailored surgical and adjuvant therapy. |
topic |
uterine cervical carcinoma HE4 biomarker prognosis serum |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.584022/full |
work_keys_str_mv |
AT elianabignotti pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT elianabignotti pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT laurazanotti pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT laurazanotti pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT paolatodeschini pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT valentinazizioli pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT chiararomani pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT davidecapoferri pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT germanatognon pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT enricosartori pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT enricosartori pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT stefanocalza pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT stefanocalza pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT stefanocalza pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT francoodicino pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT francoodicino pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT francoodicino pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT antonellaravaggi pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT antonellaravaggi pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients AT antonellaravaggi pretreatmentserumhe4levelasanovelindependentprognosticbiomarkerforuterinecervicalcarcinomapatients |
_version_ |
1724523464589574144 |
spelling |
doaj-5130fb4b05f14aa4be9ad2d0f243407e2020-11-25T03:42:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.584022584022Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma PatientsEliana Bignotti0Eliana Bignotti1Laura Zanotti2Laura Zanotti3Paola Todeschini4Valentina Zizioli5Chiara Romani6Davide Capoferri7Germana Tognon8Enrico Sartori9Enrico Sartori10Stefano Calza11Stefano Calza12Stefano Calza13Franco Odicino14Franco Odicino15Franco Odicino16Antonella Ravaggi17Antonella Ravaggi18Antonella Ravaggi19Division of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, ItalyDivision of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, ItalyDivision of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, ItalyDivision of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, ItalyDivision of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, Division of Obstetrics and Gynecology University of Brescia, Brescia, ItalyUnit of Medical Statistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, ItalyDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, SwedenBig & Open Data Innovation Laboratory (BODAI) Lab, University of Brescia, Brescia, ItalyDivision of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, Division of Obstetrics and Gynecology University of Brescia, Brescia, ItalyDivision of Obstetrics and Gynecology, Azienda Socio Sanitaria Territoriale (ASST) Spedali Civili di Brescia, Brescia, Italy“Angelo Nocivelli” Institute of Molecular Medicine, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, Division of Obstetrics and Gynecology University of Brescia, Brescia, ItalyIn spite of the effective implementation of screening programs, uterine cervical carcinoma (UCC) remains one of the major causes of cancer death among women around the world. The aim of this study was to investigate the prognostic value of serum human epididymis protein 4 (HE4) in UCC. Pre-treatment serum samples from 109 UCC patients and 99 healthy women were analyzed for HE4 levels by a quantitative chemiluminescent microparticle immunoassay on the automated ARCHITECT instrument. HE4 serum (sHE4) levels were significantly higher in UCC patients, regardless of tumor stage, compared with healthy controls. Elevated sHE4 levels were significantly associated with advanced FIGO stage and absence of disease-free interval after treatment. In univariable analysis, higher sHE4 levels were significantly correlated with shorter overall survival and progression-free survival. In multivariable analysis, sHE4 retained its significance as independent adverse prognostic factor for both survival endpoints. This study indicates that sHE4 is associated with a more aggressive tumor phenotype and a worse patient's prognosis. These results suggest the potential role of sHE4 as a novel prognostic marker and as an indicator of high-risk UCC patients for a tailored surgical and adjuvant therapy.https://www.frontiersin.org/article/10.3389/fonc.2020.584022/fulluterine cervical carcinomaHE4biomarkerprognosisserum |