ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?

<h4>Introduction</h4>While extracorporeal membrane oxygenation (ECMO) is effective in preventing further hypoxemia and maintains blood flow in endotoxin-induced shock, ECMO alone does not reverse the hypotension. In this study, we tested whether concurrent vasopressor use with ECMO would...

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Main Authors: Thornton S Mu, Amy M Becker, Aaron J Clark, Sherreen G Batts, Lee-Ann M Murata, Catherine F T Uyehara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223604
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spelling doaj-5131346a9a3940b094f4b62c10e78bac2021-03-04T10:23:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011410e022360410.1371/journal.pone.0223604ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?Thornton S MuAmy M BeckerAaron J ClarkSherreen G BattsLee-Ann M MurataCatherine F T Uyehara<h4>Introduction</h4>While extracorporeal membrane oxygenation (ECMO) is effective in preventing further hypoxemia and maintains blood flow in endotoxin-induced shock, ECMO alone does not reverse the hypotension. In this study, we tested whether concurrent vasopressor use with ECMO would provide increased circulatory support and blood flow, and characterized regional blood flow distribution to vital organs.<h4>Methods</h4>Endotoxic shock was induced in piglets to achieve a 30% decrease in mean arterial pressure (MAP). Measurements of untreated pigs were compared to pigs treated with ECMO alone or ECMO and vasopressors.<h4>Results</h4>ECMO provided cardiac support during vasodilatory endotoxic shock and improved oxygen delivery, but vasopressor therapy was required to return MAP to normotensive levels. Increased blood pressure with vasopressors did not alter oxygen consumption or extraction compared to ECMO alone. Regional microcirculatory blood flow (RBF) to the brain, kidney, and liver were maintained or increased during ECMO with and without vasopressors.<h4>Conclusion</h4>ECMO support and concurrent vasopressor use improve regional blood flow and oxygen delivery even in the absence of full blood pressure restoration. Vasopressor-induced selective distribution of blood flow to vital organs is retained when vasopressors are administered with ECMO.https://doi.org/10.1371/journal.pone.0223604
collection DOAJ
language English
format Article
sources DOAJ
author Thornton S Mu
Amy M Becker
Aaron J Clark
Sherreen G Batts
Lee-Ann M Murata
Catherine F T Uyehara
spellingShingle Thornton S Mu
Amy M Becker
Aaron J Clark
Sherreen G Batts
Lee-Ann M Murata
Catherine F T Uyehara
ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
PLoS ONE
author_facet Thornton S Mu
Amy M Becker
Aaron J Clark
Sherreen G Batts
Lee-Ann M Murata
Catherine F T Uyehara
author_sort Thornton S Mu
title ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
title_short ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
title_full ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
title_fullStr ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
title_full_unstemmed ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
title_sort ecmo with vasopressor use during early endotoxic shock: can it improve circulatory support and regional microcirculatory blood flow?
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2019-01-01
description <h4>Introduction</h4>While extracorporeal membrane oxygenation (ECMO) is effective in preventing further hypoxemia and maintains blood flow in endotoxin-induced shock, ECMO alone does not reverse the hypotension. In this study, we tested whether concurrent vasopressor use with ECMO would provide increased circulatory support and blood flow, and characterized regional blood flow distribution to vital organs.<h4>Methods</h4>Endotoxic shock was induced in piglets to achieve a 30% decrease in mean arterial pressure (MAP). Measurements of untreated pigs were compared to pigs treated with ECMO alone or ECMO and vasopressors.<h4>Results</h4>ECMO provided cardiac support during vasodilatory endotoxic shock and improved oxygen delivery, but vasopressor therapy was required to return MAP to normotensive levels. Increased blood pressure with vasopressors did not alter oxygen consumption or extraction compared to ECMO alone. Regional microcirculatory blood flow (RBF) to the brain, kidney, and liver were maintained or increased during ECMO with and without vasopressors.<h4>Conclusion</h4>ECMO support and concurrent vasopressor use improve regional blood flow and oxygen delivery even in the absence of full blood pressure restoration. Vasopressor-induced selective distribution of blood flow to vital organs is retained when vasopressors are administered with ECMO.
url https://doi.org/10.1371/journal.pone.0223604
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