Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients
We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness (<inline-formula><math display="inline"><semantics><mover accent="true...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-4601/17/22/8591 |
id |
doaj-51383b2f7f644efc94502fa77af43443 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Florent Besnier Béatrice Bérubé Christine Gagnon Miloudza Olmand Paula Aver Bretanha Ribeiro Anil Nigam Martin Juneau Lucie Blondeau Michel White Vincent Gremeaux Louis Bherer Mathieu Gayda |
spellingShingle |
Florent Besnier Béatrice Bérubé Christine Gagnon Miloudza Olmand Paula Aver Bretanha Ribeiro Anil Nigam Martin Juneau Lucie Blondeau Michel White Vincent Gremeaux Louis Bherer Mathieu Gayda Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients International Journal of Environmental Research and Public Health heart failure heart transplant cardiorespiratory fitness cognition |
author_facet |
Florent Besnier Béatrice Bérubé Christine Gagnon Miloudza Olmand Paula Aver Bretanha Ribeiro Anil Nigam Martin Juneau Lucie Blondeau Michel White Vincent Gremeaux Louis Bherer Mathieu Gayda |
author_sort |
Florent Besnier |
title |
Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients |
title_short |
Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients |
title_full |
Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients |
title_fullStr |
Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients |
title_full_unstemmed |
Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients |
title_sort |
cardiorespiratory fitness mediates cognitive performance in chronic heart failure patients and heart transplant recipients |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-11-01 |
description |
We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness (<inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub>), peak cardiac output (CO<sub>peak</sub>) and cognitive performance. Stable HT patients (<i>n</i> = 11), HF patients (<i>n</i> = 11) and HC (<i>n</i> = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC (<i>p</i> < 0.05). <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and first ventilatory threshold (VT<sub>1</sub>) were lower in HF and HT vs. HC (<i>p</i> < 0.01). CO<sub>peak</sub> was lower in HF vs. HT and HC (<i>p</i> < 0.01). Processing speed, executive function and verbal memory performances were correlated with <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub>, VT<sub>1</sub> and peak cardiac hemodynamics (<i>p</i> < 0.05). Mediation analyses showed that <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and VT<sub>1</sub> mediated the relationship between group and processing speed and executive function performances in HF and HT. CO<sub>peak</sub> fully mediated executive function and processing speed performances in HF only. <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and CO<sub>peak</sub> were related to cognitive performance in the entire sample. In addition, <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and VT<sub>1</sub> fully mediated the relationship between group and executive function and processing speed performances. |
topic |
heart failure heart transplant cardiorespiratory fitness cognition |
url |
https://www.mdpi.com/1660-4601/17/22/8591 |
work_keys_str_mv |
AT florentbesnier cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT beatriceberube cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT christinegagnon cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT miloudzaolmand cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT paulaaverbretanharibeiro cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT anilnigam cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT martinjuneau cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT lucieblondeau cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT michelwhite cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT vincentgremeaux cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT louisbherer cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients AT mathieugayda cardiorespiratoryfitnessmediatescognitiveperformanceinchronicheartfailurepatientsandhearttransplantrecipients |
_version_ |
1724419456321454080 |
spelling |
doaj-51383b2f7f644efc94502fa77af434432020-11-25T04:10:43ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-11-01178591859110.3390/ijerph17228591Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant RecipientsFlorent Besnier0Béatrice Bérubé1Christine Gagnon2Miloudza Olmand3Paula Aver Bretanha Ribeiro4Anil Nigam5Martin Juneau6Lucie Blondeau7Michel White8Vincent Gremeaux9Louis Bherer10Mathieu Gayda11Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaResearch Centre, University of Montreal Hospital Research Centre, Montreal, QC H2X 0A9, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaMontreal Health Innovations Coordinating Center, Montreal Heart Institute, Montreal, QC H1T 1C8, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaSport Medicine Unit, Division of Physical Medicine and Rehabilitation, Swiss Olympic Medical Center, Lausanne University Hospital, 1011 Lausanne, SwitzerlandPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaPreventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, CanadaWe compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness (<inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub>), peak cardiac output (CO<sub>peak</sub>) and cognitive performance. Stable HT patients (<i>n</i> = 11), HF patients (<i>n</i> = 11) and HC (<i>n</i> = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC (<i>p</i> < 0.05). <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and first ventilatory threshold (VT<sub>1</sub>) were lower in HF and HT vs. HC (<i>p</i> < 0.01). CO<sub>peak</sub> was lower in HF vs. HT and HC (<i>p</i> < 0.01). Processing speed, executive function and verbal memory performances were correlated with <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub>, VT<sub>1</sub> and peak cardiac hemodynamics (<i>p</i> < 0.05). Mediation analyses showed that <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and VT<sub>1</sub> mediated the relationship between group and processing speed and executive function performances in HF and HT. CO<sub>peak</sub> fully mediated executive function and processing speed performances in HF only. <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and CO<sub>peak</sub> were related to cognitive performance in the entire sample. In addition, <inline-formula><math display="inline"><semantics><mover accent="true"><mi>V</mi><mo>˙</mo></mover></semantics></math></inline-formula>O<sub>2peak</sub> and VT<sub>1</sub> fully mediated the relationship between group and executive function and processing speed performances.https://www.mdpi.com/1660-4601/17/22/8591heart failureheart transplantcardiorespiratory fitnesscognition |