Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model
Fucoxanthin is a carotenoid with many pharmaceutical properties that is found in brown seaweed. However, the effects of fucoxanthin on corneal innervation and intense eye pain have not been extensively examined. To clarify the protective roles and underlying mechanisms of fucoxanthin on ocular lesio...
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doaj-513a7e98951447e48265fec67ffc99472020-11-24T21:37:15ZengMDPI AGMarine Drugs1660-33972019-03-0117315210.3390/md17030152md17030152Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat ModelShiu-Jau Chen0Ching-Ju Lee1Tzer-Bin Lin2Hsien-Yu Peng3Hsiang-Jui Liu4Yu-Shan Chen5Kuang-Wen Tseng6Department of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, TaiwanInternal Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei 24213, TaiwanDepartment of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11049, TaiwanDepartment of Medicine, Mackay Medical College, New Taipei 25245, TaiwanDepartment of Optometry, Mackay Junior College of Medicine, Nursing and Management, New Taipei 11260, TaiwanDepartment of Business Administration, National Taipei University, New Taipei 24741, TaiwanDepartment of Medicine, Mackay Medical College, New Taipei 25245, TaiwanFucoxanthin is a carotenoid with many pharmaceutical properties that is found in brown seaweed. However, the effects of fucoxanthin on corneal innervation and intense eye pain have not been extensively examined. To clarify the protective roles and underlying mechanisms of fucoxanthin on ocular lesions, we investigated the beneficial effects and mechanisms by which fucoxanthin ameliorates ultraviolet B (UVB)-induced corneal denervation and trigeminal pain. Treatment with fucoxanthin enhanced the expression of nuclear factor erythroid 2-related factor 2 in the cornea. Inhibition of typical denervation and epithelial exfoliation in the cornea were observed in rats treated with fucoxanthin following UVB-induced nerve disorders. Moreover, the active phosphorylated form of p38 MAP kinase (pp38) and the number of glial fibrillary acidic protein (GFAP)-positive neural cells were significantly reduced. Decreased expression of neuron-selective transient receptor potential vanilloid type 1 (TRPV1) in the trigeminal ganglia neurons was also demonstrated in rats treated with fucoxanthin after UVB-induced keratitis. Symptoms of inflammatory pain, including difficulty in opening the eyes and eye wipe behaviour, were also reduced in fucoxanthin-treated groups. Pre-treatment with fucoxanthin may protect the eyes from denervation and inhibit trigeminal pain in UVB-induced photokeratitis models.http://www.mdpi.com/1660-3397/17/3/152fucoxanthinultraviolet Bdenervation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shiu-Jau Chen Ching-Ju Lee Tzer-Bin Lin Hsien-Yu Peng Hsiang-Jui Liu Yu-Shan Chen Kuang-Wen Tseng |
spellingShingle |
Shiu-Jau Chen Ching-Ju Lee Tzer-Bin Lin Hsien-Yu Peng Hsiang-Jui Liu Yu-Shan Chen Kuang-Wen Tseng Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model Marine Drugs fucoxanthin ultraviolet B denervation |
author_facet |
Shiu-Jau Chen Ching-Ju Lee Tzer-Bin Lin Hsien-Yu Peng Hsiang-Jui Liu Yu-Shan Chen Kuang-Wen Tseng |
author_sort |
Shiu-Jau Chen |
title |
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model |
title_short |
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model |
title_full |
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model |
title_fullStr |
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model |
title_full_unstemmed |
Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model |
title_sort |
protective effects of fucoxanthin on ultraviolet b-induced corneal denervation and inflammatory pain in a rat model |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2019-03-01 |
description |
Fucoxanthin is a carotenoid with many pharmaceutical properties that is found in brown seaweed. However, the effects of fucoxanthin on corneal innervation and intense eye pain have not been extensively examined. To clarify the protective roles and underlying mechanisms of fucoxanthin on ocular lesions, we investigated the beneficial effects and mechanisms by which fucoxanthin ameliorates ultraviolet B (UVB)-induced corneal denervation and trigeminal pain. Treatment with fucoxanthin enhanced the expression of nuclear factor erythroid 2-related factor 2 in the cornea. Inhibition of typical denervation and epithelial exfoliation in the cornea were observed in rats treated with fucoxanthin following UVB-induced nerve disorders. Moreover, the active phosphorylated form of p38 MAP kinase (pp38) and the number of glial fibrillary acidic protein (GFAP)-positive neural cells were significantly reduced. Decreased expression of neuron-selective transient receptor potential vanilloid type 1 (TRPV1) in the trigeminal ganglia neurons was also demonstrated in rats treated with fucoxanthin after UVB-induced keratitis. Symptoms of inflammatory pain, including difficulty in opening the eyes and eye wipe behaviour, were also reduced in fucoxanthin-treated groups. Pre-treatment with fucoxanthin may protect the eyes from denervation and inhibit trigeminal pain in UVB-induced photokeratitis models. |
topic |
fucoxanthin ultraviolet B denervation |
url |
http://www.mdpi.com/1660-3397/17/3/152 |
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