Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients
Aim. To study efficiency and safety of hydroxizine (H) and tofisopam (T) therapy in DM patients with generalized organic anxiety disorders and subsyndromicanxiety the overall prevalence of which among diabetic patients amounts to 45-50%. Materials and methods. This open prospective randomized c...
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doaj-515615d0a534444691ee6ae05f6cc5de2021-06-02T21:37:32ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782010-09-01133525510.14341/2072-0351-54885446Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patientsElena Georgievna Starostina0Elena Nikolaevna Moshnyaga1Aleksey Evgen'evich Bobrov2Московский НИИ психиатрии, МоскваГУ Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского, МоскваГУ Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского, Москва; Московский НИИ психиатрии, МоскваAim. To study efficiency and safety of hydroxizine (H) and tofisopam (T) therapy in DM patients with generalized organic anxiety disorders and subsyndromicanxiety the overall prevalence of which among diabetic patients amounts to 45-50%. Materials and methods. This open prospective randomized comparative study included 60 DM patients with anxiety disorders (AD) of whom 95%presented with arterial hypertension. The medicines were prescribed at mean therapeutic doses for 3 months followed by 1 month withdrawal period.The efficiency of anxiolytics was estimated from dynamic patterns of reactive anxiety (RA), personal anxiety (PA, Spielberger scale), somatic anxietysymptoms (Giessen questionnaire), HbA1c level, systolic and diastolic AP (SAP, DAP), heart rate. Results. Therapy with anxiolytics for 3 months resulted in the decrease of the HbA1c level from 7.9?1.4 to 7.4?1.4%, total somatic anxiety scorefrom 38.0?13.2 to 31.5?12.2, PA from 52.5?9.7 to 47.1?8.8, RA from 32.3?9.0 to 25.5?9.3, SAP from 141.4?12.4 to 129.8?13.5 mmHg,DAP from 82.3?7.4 to 77.8?8.6 mm Hg, HR from 76.3?9.5 to 72.7-5.6 (in all cases phttps://dia-endojournals.ru/dia/article/viewFile/5488/3286diabetes mellitusanxiety disorderstherapyhydroxizinetofisopam |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elena Georgievna Starostina Elena Nikolaevna Moshnyaga Aleksey Evgen'evich Bobrov |
spellingShingle |
Elena Georgievna Starostina Elena Nikolaevna Moshnyaga Aleksey Evgen'evich Bobrov Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients Сахарный диабет diabetes mellitus anxiety disorders therapy hydroxizine tofisopam |
author_facet |
Elena Georgievna Starostina Elena Nikolaevna Moshnyaga Aleksey Evgen'evich Bobrov |
author_sort |
Elena Georgievna Starostina |
title |
Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients |
title_short |
Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients |
title_full |
Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients |
title_fullStr |
Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients |
title_full_unstemmed |
Efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients |
title_sort |
efficacy and safety of medical treatment of chronic anxiety disorders in diabetic patients |
publisher |
Endocrinology Research Centre |
series |
Сахарный диабет |
issn |
2072-0351 2072-0378 |
publishDate |
2010-09-01 |
description |
Aim.
To study efficiency and safety of hydroxizine (H) and tofisopam (T) therapy in DM patients with generalized organic anxiety disorders and subsyndromicanxiety the overall prevalence of which among diabetic patients amounts to 45-50%.
Materials and methods.
This open prospective randomized comparative study included 60 DM patients with anxiety disorders (AD) of whom 95%presented with arterial hypertension. The medicines were prescribed at mean therapeutic doses for 3 months followed by 1 month withdrawal period.The efficiency of anxiolytics was estimated from dynamic patterns of reactive anxiety (RA), personal anxiety (PA, Spielberger scale), somatic anxietysymptoms (Giessen questionnaire), HbA1c level, systolic and diastolic AP (SAP, DAP), heart rate.
Results.
Therapy with anxiolytics for 3 months resulted in the decrease of the HbA1c level from 7.9?1.4 to 7.4?1.4%, total somatic anxiety scorefrom 38.0?13.2 to 31.5?12.2, PA from 52.5?9.7 to 47.1?8.8, RA from 32.3?9.0 to 25.5?9.3, SAP from 141.4?12.4 to 129.8?13.5 mmHg,DAP from 82.3?7.4 to 77.8?8.6 mm Hg, HR from 76.3?9.5 to 72.7-5.6 (in all cases p |
topic |
diabetes mellitus anxiety disorders therapy hydroxizine tofisopam |
url |
https://dia-endojournals.ru/dia/article/viewFile/5488/3286 |
work_keys_str_mv |
AT elenageorgievnastarostina efficacyandsafetyofmedicaltreatmentofchronicanxietydisordersindiabeticpatients AT elenanikolaevnamoshnyaga efficacyandsafetyofmedicaltreatmentofchronicanxietydisordersindiabeticpatients AT alekseyevgenevichbobrov efficacyandsafetyofmedicaltreatmentofchronicanxietydisordersindiabeticpatients |
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1721400449797455872 |