Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.
Bibliographic Details
| Main Authors: |
Xin Chen,
Na Liu,
Liquan Liu,
Wei Chen,
Na Chen,
Meng Lin,
Jiaju Xu,
Xing Zhou,
Hongbo Wang,
Meiping Zhao,
Xianjin Xiao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-12593-9
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