The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice

The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice

Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles. The expression levels of DGKs are comparative...

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Main Authors: Mitsue Ishisaka, Hideaki Hara
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319301847
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spelling doaj-5178af3061804e98b421614d4561c7cd2020-11-24T23:52:10ZengElsevierJournal of Pharmacological Sciences1347-86132014-01-011243336343The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in MiceMitsue Ishisaka0Hideaki Hara1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, JapanMolecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan; Corresponding author. hidehara@gifu-pu.ac.jpDiacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles. The expression levels of DGKs are comparatively higher in the central nervous system than in other organs and may play several important roles in regulating higher brain functions. Currently, many studies have been performed to reveal the roles of DGKs by knocking down or overexpression of DGKs in vitro. Additionally, knockout or overexpression mice of several DGKs have been generated, and phenotypes of these mice have been studied. In this review, we discuss the roles of DGKs in the central nervous system based on recent findings in genetic models. Keywords:: central nervous system, diacylglycerol kinase, genetic mouse, mood disorderhttp://www.sciencedirect.com/science/article/pii/S1347861319301847
collection DOAJ
language English
format Article
sources DOAJ
author Mitsue Ishisaka
Hideaki Hara
spellingShingle Mitsue Ishisaka
Hideaki Hara
The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
Journal of Pharmacological Sciences
author_facet Mitsue Ishisaka
Hideaki Hara
author_sort Mitsue Ishisaka
title The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
title_short The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
title_full The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
title_fullStr The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
title_full_unstemmed The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
title_sort roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2014-01-01
description Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles. The expression levels of DGKs are comparatively higher in the central nervous system than in other organs and may play several important roles in regulating higher brain functions. Currently, many studies have been performed to reveal the roles of DGKs by knocking down or overexpression of DGKs in vitro. Additionally, knockout or overexpression mice of several DGKs have been generated, and phenotypes of these mice have been studied. In this review, we discuss the roles of DGKs in the central nervous system based on recent findings in genetic models. Keywords:: central nervous system, diacylglycerol kinase, genetic mouse, mood disorder
url http://www.sciencedirect.com/science/article/pii/S1347861319301847
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