Cardiac computed tomography-derived extracellular volume fraction in late anthracycline-induced cardiotoxicity

• Main Authors: Koichi Egashira, Daisuke Sueta, Mai Tomiguchi, Masafumi Kidoh, Seitaro Oda, Hiroki Usuku, Kaori Hidaka, Lisa Goto-Yamaguchi, Aiko Sueta, Takashi Komorita, Masafumi Takae, Fumi Oike, Koichiro Fujisue, Eiichiro Yamamoto, Shinsuke Hanatani, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Koichi Kaikita, Kenichi Matsushita, Yutaka Yamamoto, Toshinori Hirai, Kenichi Tsujita
• Format: Article
• Language: English
• Published: Elsevier 2021-06-01
• Series: International Journal of Cardiology: Heart & Vasculature
• Subjects: Cardio-oncology; Cardiotoxicity; Anthracycline; Cardiac computed tomography
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352906721000853

Cardiotoxicity in the late phase after anthracycline drugs administration remains to be defined. Of the 44 patients who received anthracycline treatment, 7 were found to have cancer therapeutics–related cardiac dysfunction (CTRCD). The global longitudinal strain determined by echocardiography and myocardial extracellular volume fraction (ECV) determined by cardiac computed tomography (CCT) of the CTRCD(+) group were significantly higher than those of the control group and CTRCD(-) group, whereas there were no significant differences between the control and CTRCD(-) groups. Our findings indicated that CCT may be a tool comparable to echocardiography, indicating the effective evaluation of CTRCD by CCT.