Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease

Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disease. Pathologically, PD is characterized by the formation of Lewy bodies (LBs) in the brain, which mainly comprises phosphorylated and aggregated α-synuclein (α-syn). The aberrant aggregation of α-syn is believed to play a...

Full description

Bibliographic Details
Main Authors: Jiaolong Yang, Shilin Luo, Jichun Zhang, Ting Yu, Zhihui Fu, Yongfa Zheng, Ximing Xu, Chaoyang Liu, Mingxia Fan, Zhentao Zhang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Exosomes
Antisense oligonucleotides
α-synuclein
Phosphorylated α-synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304939

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120304939

Similar Items