Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disease. Pathologically, PD is characterized by the formation of Lewy bodies (LBs) in the brain, which mainly comprises phosphorylated and aggregated α-synuclein (α-syn). The aberrant aggregation of α-syn is believed to play a...
Main Authors: | Jiaolong Yang, Shilin Luo, Jichun Zhang, Ting Yu, Zhihui Fu, Yongfa Zheng, Ximing Xu, Chaoyang Liu, Mingxia Fan, Zhentao Zhang |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120304939 |
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