Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study
Fuchu Qian,1 Weihua Zou,2 Jiqu Qin,1 Dongli Li11Huzhou Key Laboratory of Molecular Medicine, 2Department of Laboratory Medicine, Huzhou Central Hospital, Huzhou, ChinaChina is an area with highly endemic hepatitis B virus (HBV) infection, with an estimated 93 million HBV carriers, resulting in appro...
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doaj-518e90e74c4f462781bc9d25a41317732020-11-24T22:28:52ZengDove Medical PressInfection and Drug Resistance1178-69732017-12-01Volume 1050750935995Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center studyQian FZou WQin JLi DFuchu Qian,1 Weihua Zou,2 Jiqu Qin,1 Dongli Li11Huzhou Key Laboratory of Molecular Medicine, 2Department of Laboratory Medicine, Huzhou Central Hospital, Huzhou, ChinaChina is an area with highly endemic hepatitis B virus (HBV) infection, with an estimated 93 million HBV carriers, resulting in approximately 330,000 deaths annually.1 The predominant HBV genotypes in China are genotype B and C. Currently, nucleos(t)ide analogs are used for anti-HBV treatment. However, prolonged antiviral therapy may lead to drug resistance, which is associated with mutations in the reverse transcriptase region of the HBV genome. Several studies have shown that drug-resistant mutations existed in treatment-naïve patients with chronic hepatitis B (CHB). However, the prevalence rates of natural drug-resistant mutations varied in different reports.2,3 Furthermore, the prevalence and clinical profile of natural drug-resistant mutations in CHB patients are not quite clear. Thus, the purpose of this study was to investigate the prevalence and clinical feature of natural drug-resistant mutations among treatmentnaïve CHB patients in a tertiary hospital in Huzhou, eastern China.https://www.dovepress.com/naturally-occurring-genotypic-drug-resistant-mutations-of-hbv-in-huzho-peer-reviewed-article-IDREastern china Hepatitis B virus mutation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qian F Zou W Qin J Li D |
spellingShingle |
Qian F Zou W Qin J Li D Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study Infection and Drug Resistance Eastern china Hepatitis B virus mutation |
author_facet |
Qian F Zou W Qin J Li D |
author_sort |
Qian F |
title |
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study |
title_short |
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study |
title_full |
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study |
title_fullStr |
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study |
title_full_unstemmed |
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study |
title_sort |
naturally occurring genotypic drug-resistant mutations of hbv in huzhou, china: a single-center study |
publisher |
Dove Medical Press |
series |
Infection and Drug Resistance |
issn |
1178-6973 |
publishDate |
2017-12-01 |
description |
Fuchu Qian,1 Weihua Zou,2 Jiqu Qin,1 Dongli Li11Huzhou Key Laboratory of Molecular Medicine, 2Department of Laboratory Medicine, Huzhou Central Hospital, Huzhou, ChinaChina is an area with highly endemic hepatitis B virus (HBV) infection, with an estimated 93 million HBV carriers, resulting in approximately 330,000 deaths annually.1 The predominant HBV genotypes in China are genotype B and C. Currently, nucleos(t)ide analogs are used for anti-HBV treatment. However, prolonged antiviral therapy may lead to drug resistance, which is associated with mutations in the reverse transcriptase region of the HBV genome. Several studies have shown that drug-resistant mutations existed in treatment-naïve patients with chronic hepatitis B (CHB). However, the prevalence rates of natural drug-resistant mutations varied in different reports.2,3 Furthermore, the prevalence and clinical profile of natural drug-resistant mutations in CHB patients are not quite clear. Thus, the purpose of this study was to investigate the prevalence and clinical feature of natural drug-resistant mutations among treatmentnaïve CHB patients in a tertiary hospital in Huzhou, eastern China. |
topic |
Eastern china Hepatitis B virus mutation |
url |
https://www.dovepress.com/naturally-occurring-genotypic-drug-resistant-mutations-of-hbv-in-huzho-peer-reviewed-article-IDR |
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