Blood hyperviscosity identification with reflective spectroscopy of tongue tip based on principal component analysis combining artificial neural network

• Main Authors: Ming Liu, Jing Zhao, XiaoZuo Lu, Gang Li, Taixia Wu, LiFu Zhang
• Format: Article
• Language: English
• Published: BMC 2018-05-01
• Series: BioMedical Engineering OnLine
• Subjects: Reflective spectroscopy; Noninvasive; Blood hyperviscosity diagnosis; Principal component analysis; Artificial neural network
• Online Access: http://link.springer.com/article/10.1186/s12938-018-0495-3

Abstract Background With spectral methods, noninvasive determination of blood hyperviscosity in vivo is very potential and meaningful in clinical diagnosis. In this study, 67 male subjects (41 health, and 26 hyperviscosity according to blood sample analysis results) participate. Methods Reflectance spectra of subjects’ tongue tips is measured, and a classification method bases on principal component analysis combined with artificial neural network model is built to identify hyperviscosity. Hold-out and Leave-one-out methods are used to avoid significant bias and lessen overfitting problem, which are widely accepted in the model validation. Results To measure the performance of the classification, sensitivity, specificity, accuracy and F-measure are calculated, respectively. The accuracies with 100 times Hold-out method and 67 times Leave-one-out method are 88.05% and 97.01%, respectively. Conclusions Experimental results indicate that the built classification model has certain practical value and proves the feasibility of using spectroscopy to identify hyperviscosity by noninvasive determination.