Muscles adaptation to aging and training: architectural changes – a randomised trial
Abstract Background To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo. Methods The old participants were randomly assigned to moderate (O55, n = 13) or high-load...
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doaj-519712c0255c4d4ea747da9be6ad09ac2021-01-17T12:10:29ZengBMCBMC Geriatrics1471-23182021-01-0121111810.1186/s12877-020-02000-0Muscles adaptation to aging and training: architectural changes – a randomised trialAdrien J. Létocart0Franck Mabesoone1Fabrice Charleux2Christian Couppé3René B. Svensson4Frédéric Marin5S. Peter Magnusson6Jean-François Grosset7Sorbonne Universités, Biomécanique et Bioingénierie, Université de Technologie de Compiègne, UMR CNRS 7338Centre Hospitalier COMPIÈGNE-NOYONACRIM-Polyclinique Saint CômeInstitute of Sports Medicine Copenhagen / Dept of Physical Therapy, Bispebjerg HospitalInstitute of Sports Medicine Copenhagen / Dept of Physical Therapy, Bispebjerg HospitalSorbonne Universités, Biomécanique et Bioingénierie, Université de Technologie de Compiègne, UMR CNRS 7338Institute of Sports Medicine Copenhagen / Dept of Physical Therapy, Bispebjerg HospitalSorbonne Universités, Biomécanique et Bioingénierie, Université de Technologie de Compiègne, UMR CNRS 7338Abstract Background To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo. Methods The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans. Results Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed. Conclusions Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass. Trial registration NCT03079180 in ClinicalTrials.gov . Registration date: March 14, 2017.https://doi.org/10.1186/s12877-020-02000-0Muscle volumeResistance trainingAgeingAnatomical cross-sectional areaNon-contractile tissue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adrien J. Létocart Franck Mabesoone Fabrice Charleux Christian Couppé René B. Svensson Frédéric Marin S. Peter Magnusson Jean-François Grosset |
spellingShingle |
Adrien J. Létocart Franck Mabesoone Fabrice Charleux Christian Couppé René B. Svensson Frédéric Marin S. Peter Magnusson Jean-François Grosset Muscles adaptation to aging and training: architectural changes – a randomised trial BMC Geriatrics Muscle volume Resistance training Ageing Anatomical cross-sectional area Non-contractile tissue |
author_facet |
Adrien J. Létocart Franck Mabesoone Fabrice Charleux Christian Couppé René B. Svensson Frédéric Marin S. Peter Magnusson Jean-François Grosset |
author_sort |
Adrien J. Létocart |
title |
Muscles adaptation to aging and training: architectural changes – a randomised trial |
title_short |
Muscles adaptation to aging and training: architectural changes – a randomised trial |
title_full |
Muscles adaptation to aging and training: architectural changes – a randomised trial |
title_fullStr |
Muscles adaptation to aging and training: architectural changes – a randomised trial |
title_full_unstemmed |
Muscles adaptation to aging and training: architectural changes – a randomised trial |
title_sort |
muscles adaptation to aging and training: architectural changes – a randomised trial |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2021-01-01 |
description |
Abstract Background To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo. Methods The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans. Results Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed. Conclusions Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass. Trial registration NCT03079180 in ClinicalTrials.gov . Registration date: March 14, 2017. |
topic |
Muscle volume Resistance training Ageing Anatomical cross-sectional area Non-contractile tissue |
url |
https://doi.org/10.1186/s12877-020-02000-0 |
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