8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists
Both acute and chronic ingestion of 2S-hesperidin have shown antioxidant and anti-inflammatory effects in animal studies, but so far, no one has studied this effect of chronic ingestion in humans. The main objective was to evaluate whether an 8-week intake of 2S-hesperidin had the ability to modulat...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
|
Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/10/3/432 |
id |
doaj-519941e121f043d3b5e0b0ffc6883146 |
---|---|
record_format |
Article |
spelling |
doaj-519941e121f043d3b5e0b0ffc68831462021-03-12T00:05:49ZengMDPI AGAntioxidants2076-39212021-03-011043243210.3390/antiox100304328-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur CyclistsFrancisco Javier Martínez-Noguera0Cristian Marín-Pagán1Jorge Carlos-Vivas2Pedro E. Alcaraz3Research Center for High Performance Sport, Catholic University of Murcia, Campus de los Jerónimos Nº 135, UCAM, 30107 Murcia, SpainResearch Center for High Performance Sport, Catholic University of Murcia, Campus de los Jerónimos Nº 135, UCAM, 30107 Murcia, SpainHealth, Economy, Motricity and Education Research Group (HEME), Faculty of Sport Sciences, University of Extremadura. Avda. de Elvas, s/n., 06006 Badajoz, SpainResearch Center for High Performance Sport, Catholic University of Murcia, Campus de los Jerónimos Nº 135, UCAM, 30107 Murcia, SpainBoth acute and chronic ingestion of 2S-hesperidin have shown antioxidant and anti-inflammatory effects in animal studies, but so far, no one has studied this effect of chronic ingestion in humans. The main objective was to evaluate whether an 8-week intake of 2S-hesperidin had the ability to modulate antioxidant-oxidant and inflammatory status in amateur cyclists. A parallel, randomized, double-blind, placebo-controlled trial study was carried out with two groups (500 mg/d 2S-hesperidin; <i>n</i> = 20 and 500 mg/d placebo; <i>n</i> = 20). An incremental test was performed to determine the working zones in a rectangular test, which was used to analyze for changes in antioxidant and inflammatory biomarkers. After 2S-hesperidin ingestion, we found in the rectangular test: (1) an increase in superoxide dismutase (SOD) after the exercise phase until exhaustion (<i>p </i>= 0.045) and the acute recovery phase (<i>p</i> = 0.004), (2) a decrease in the area under the oxidized glutathione curve (GSSG) (<i>p</i> = 0.016), and (3) a decrease in monocyte chemoattractant protein 1 (MCP1) after the acute recovery phase (<i>p</i> = 0.004), post-intervention. Chronic 2S-hesperidin supplementation increased endogenous antioxidant capacity (↑SOD) after maximal effort and decreased oxidative stress (↓AUC-GSSG) during the rectangular test, decreasing inflammation (↓MCP1) after the acute recovery phase.https://www.mdpi.com/2076-3921/10/3/432polyphenolsflavonidsendogenous antioxidant enzymesreduced glutathioneoxidized glutathionecatalase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francisco Javier Martínez-Noguera Cristian Marín-Pagán Jorge Carlos-Vivas Pedro E. Alcaraz |
spellingShingle |
Francisco Javier Martínez-Noguera Cristian Marín-Pagán Jorge Carlos-Vivas Pedro E. Alcaraz 8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists Antioxidants polyphenols flavonids endogenous antioxidant enzymes reduced glutathione oxidized glutathione catalase |
author_facet |
Francisco Javier Martínez-Noguera Cristian Marín-Pagán Jorge Carlos-Vivas Pedro E. Alcaraz |
author_sort |
Francisco Javier Martínez-Noguera |
title |
8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists |
title_short |
8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists |
title_full |
8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists |
title_fullStr |
8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists |
title_full_unstemmed |
8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists |
title_sort |
8-week supplementation of 2s-hesperidin modulates antioxidant and inflammatory status after exercise until exhaustion in amateur cyclists |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2021-03-01 |
description |
Both acute and chronic ingestion of 2S-hesperidin have shown antioxidant and anti-inflammatory effects in animal studies, but so far, no one has studied this effect of chronic ingestion in humans. The main objective was to evaluate whether an 8-week intake of 2S-hesperidin had the ability to modulate antioxidant-oxidant and inflammatory status in amateur cyclists. A parallel, randomized, double-blind, placebo-controlled trial study was carried out with two groups (500 mg/d 2S-hesperidin; <i>n</i> = 20 and 500 mg/d placebo; <i>n</i> = 20). An incremental test was performed to determine the working zones in a rectangular test, which was used to analyze for changes in antioxidant and inflammatory biomarkers. After 2S-hesperidin ingestion, we found in the rectangular test: (1) an increase in superoxide dismutase (SOD) after the exercise phase until exhaustion (<i>p </i>= 0.045) and the acute recovery phase (<i>p</i> = 0.004), (2) a decrease in the area under the oxidized glutathione curve (GSSG) (<i>p</i> = 0.016), and (3) a decrease in monocyte chemoattractant protein 1 (MCP1) after the acute recovery phase (<i>p</i> = 0.004), post-intervention. Chronic 2S-hesperidin supplementation increased endogenous antioxidant capacity (↑SOD) after maximal effort and decreased oxidative stress (↓AUC-GSSG) during the rectangular test, decreasing inflammation (↓MCP1) after the acute recovery phase. |
topic |
polyphenols flavonids endogenous antioxidant enzymes reduced glutathione oxidized glutathione catalase |
url |
https://www.mdpi.com/2076-3921/10/3/432 |
work_keys_str_mv |
AT franciscojaviermartineznoguera 8weeksupplementationof2shesperidinmodulatesantioxidantandinflammatorystatusafterexerciseuntilexhaustioninamateurcyclists AT cristianmarinpagan 8weeksupplementationof2shesperidinmodulatesantioxidantandinflammatorystatusafterexerciseuntilexhaustioninamateurcyclists AT jorgecarlosvivas 8weeksupplementationof2shesperidinmodulatesantioxidantandinflammatorystatusafterexerciseuntilexhaustioninamateurcyclists AT pedroealcaraz 8weeksupplementationof2shesperidinmodulatesantioxidantandinflammatorystatusafterexerciseuntilexhaustioninamateurcyclists |
_version_ |
1724223378421710848 |