Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury

Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury

The adult heart following injury such as a myocardial infarction forms a fibrotic scar associated with transformation of resident cardiac fibroblasts into myofibroblast, accelerating cardiac remodeling and dysfunction. Cell therapies provide a novel direction for the enhancement of cardiac structure...

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Bibliographic Details
Main Authors: Lindsay Kraus, Lena Ma, Yijun Yang, Faustina Nguyen, Robert C. Hoy, Tomoko Okuno, Mohsin Khan, Sadia Mohsin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
stem cells
cardiac fibrosis
myocardial infarction
fibroblasts
miR-18a
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00494/full

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