Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy
Objectives: In laparoscopic cholecystectomy, there has been emphasis on maintaining hemodynamic stability by avoiding hypertension, hypotension, or tachycardia. The hemodynamic instability is persistent during the duration of pneumoperitoneum (PNP), namely, CO2 insufflations. This study helps us to...
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doaj-519d93d2861f46ebab00e7050557ad122021-04-02T16:17:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.International Journal of Recent Surgical and Medical Sciences2455-74202455-09492018-01-01040101001410.5005/jp-journals-10053-0063Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic CholecystectomyHimanshu Dodeja Resident0Vinaya Udaybhaskar Resident1Amol Singam Professor2Department of Anesthesiology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, IndiaDepartment of Anesthesiology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, IndiaDepartment of Anesthesiology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, IndiaObjectives: In laparoscopic cholecystectomy, there has been emphasis on maintaining hemodynamic stability by avoiding hypertension, hypotension, or tachycardia. The hemodynamic instability is persistent during the duration of pneumoperitoneum (PNP), namely, CO2 insufflations. This study helps us to find out the efficacy of dexmedetomidine on cardiovascular system stability in patients undergoing laparoscopic cholecystectomy. Materials and methods: Thirty patients were randomized into two groups of 15 members each: group P (placebo group) and group D (dexmedetomidine group). In the former, patients received 0.9% 20 mL normal saline, while in the latter, patients received 0.4 μg/kg/hr of injection dexmedetomidine in 0.9% normal saline. In all patients, age, weight, height, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded. Results: Dexmedetomidine being a highly selective and potent and specific alpha 2 agonist attenuates the hemodynamic response to tracheal intubation, decreases plasma catecholamine concentration during anesthesia, and decreases perioperative requirements of inhaled anesthetics. We found that dexmedetomidine helped in blunting the pressor response during the intubation, kept the HR and mean arterial pressure stable intraoperatively, and there was faster recovery as the requirement of inhalation agent was decreased intraoperatively. Conclusion: The drug dexmedetomidine maintained cardiovascular stability during laparoscopic cholecystectomy. The inhalational agent (isoflurane) requirement was found to be considerably lower. Also, the mean recovery time as indicated by the ability to vocalize following extubation was found to be significantly less. Hence, it can be recommended in laparoscopic cholecystectomy for maintaining cardiovascular system stability.http://www.thieme-connect.de/DOI/DOI?10.5005/jp-journals-10053-0063cardiovascular stabilitydexmedetomidinelaparoscopic cholecystectomypost-op recovery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Himanshu Dodeja Resident Vinaya Udaybhaskar Resident Amol Singam Professor |
spellingShingle |
Himanshu Dodeja Resident Vinaya Udaybhaskar Resident Amol Singam Professor Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy International Journal of Recent Surgical and Medical Sciences cardiovascular stability dexmedetomidine laparoscopic cholecystectomy post-op recovery |
author_facet |
Himanshu Dodeja Resident Vinaya Udaybhaskar Resident Amol Singam Professor |
author_sort |
Himanshu Dodeja Resident |
title |
Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy |
title_short |
Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy |
title_full |
Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy |
title_fullStr |
Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy |
title_full_unstemmed |
Effects of Dexmedetomidine Infusions on Hemodynamic Stability in Patients undergoing Laparoscopic Cholecystectomy |
title_sort |
effects of dexmedetomidine infusions on hemodynamic stability in patients undergoing laparoscopic cholecystectomy |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
International Journal of Recent Surgical and Medical Sciences |
issn |
2455-7420 2455-0949 |
publishDate |
2018-01-01 |
description |
Objectives: In laparoscopic cholecystectomy, there has been emphasis on maintaining hemodynamic stability by avoiding hypertension, hypotension, or tachycardia. The hemodynamic instability is persistent during the duration of pneumoperitoneum (PNP), namely, CO2 insufflations. This study helps us to find out the efficacy of dexmedetomidine on cardiovascular system stability in patients undergoing laparoscopic cholecystectomy.
Materials and methods: Thirty patients were randomized into two groups of 15 members each: group P (placebo group) and group D (dexmedetomidine group). In the former, patients received 0.9% 20 mL normal saline, while in the latter, patients received 0.4 μg/kg/hr of injection dexmedetomidine in 0.9% normal saline. In all patients, age, weight, height, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded.
Results: Dexmedetomidine being a highly selective and potent and specific alpha 2 agonist attenuates the hemodynamic response to tracheal intubation, decreases plasma catecholamine concentration during anesthesia, and decreases perioperative requirements of inhaled anesthetics. We found that dexmedetomidine helped in blunting the pressor response during the intubation, kept the HR and mean arterial pressure stable intraoperatively, and there was faster recovery as the requirement of inhalation agent was decreased intraoperatively.
Conclusion: The drug dexmedetomidine maintained cardiovascular stability during laparoscopic cholecystectomy. The inhalational agent (isoflurane) requirement was found to be considerably lower. Also, the mean recovery time as indicated by the ability to vocalize following extubation was found to be significantly less. Hence, it can be recommended in laparoscopic cholecystectomy for maintaining cardiovascular system stability. |
topic |
cardiovascular stability dexmedetomidine laparoscopic cholecystectomy post-op recovery |
url |
http://www.thieme-connect.de/DOI/DOI?10.5005/jp-journals-10053-0063 |
work_keys_str_mv |
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