Cardiac Glucolipotoxicity and Cardiovascular Outcomes
Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery dise...
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MDPI AG
2018-10-01
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| Series: | Medicina |
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| Online Access: | http://www.mdpi.com/1010-660X/54/5/70 |
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doaj-51b09837a8a84bdf92af4ea066eee2562020-11-24T21:53:03ZengMDPI AGMedicina1010-660X2018-10-015457010.3390/medicina54050070medicina54050070Cardiac Glucolipotoxicity and Cardiovascular OutcomesMarlon E. Cerf0Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South AfricaCardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function.http://www.mdpi.com/1010-660X/54/5/70bioenergeticscardiac developmentdiabetesfatty acidsglucose transporthyperglycemia |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marlon E. Cerf |
| spellingShingle |
Marlon E. Cerf Cardiac Glucolipotoxicity and Cardiovascular Outcomes Medicina bioenergetics cardiac development diabetes fatty acids glucose transport hyperglycemia |
| author_facet |
Marlon E. Cerf |
| author_sort |
Marlon E. Cerf |
| title |
Cardiac Glucolipotoxicity and Cardiovascular Outcomes |
| title_short |
Cardiac Glucolipotoxicity and Cardiovascular Outcomes |
| title_full |
Cardiac Glucolipotoxicity and Cardiovascular Outcomes |
| title_fullStr |
Cardiac Glucolipotoxicity and Cardiovascular Outcomes |
| title_full_unstemmed |
Cardiac Glucolipotoxicity and Cardiovascular Outcomes |
| title_sort |
cardiac glucolipotoxicity and cardiovascular outcomes |
| publisher |
MDPI AG |
| series |
Medicina |
| issn |
1010-660X |
| publishDate |
2018-10-01 |
| description |
Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function. |
| topic |
bioenergetics cardiac development diabetes fatty acids glucose transport hyperglycemia |
| url |
http://www.mdpi.com/1010-660X/54/5/70 |
| work_keys_str_mv |
AT marlonecerf cardiacglucolipotoxicityandcardiovascularoutcomes |
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