Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes
Hypereosinophilia (HE) is a heterogeneous condition with a persistent elevated eosinophil count of >350/mm<sup>3</sup>, which is reported in various (inflammatory, allergic, infectious, or neoplastic) diseases with distinct pathophysiological pathways. HE may be associated with tissue...
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doaj-51b1272d8810421689935bf5801f17072021-01-07T00:02:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-012248648610.3390/ijms22020486Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic SyndromesStefania Stella0Michele Massimino1Livia Manzella2Maria Stella Pennisi3Elena Tirrò4Chiara Romano5Silvia Rita Vitale6Adriana Puma7Cristina Tomarchio8Sandra Di Gregorio9Giuseppe Alberto Palumbo10Paolo Vigneri11Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Scienze Mediche Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyHypereosinophilia (HE) is a heterogeneous condition with a persistent elevated eosinophil count of >350/mm<sup>3</sup>, which is reported in various (inflammatory, allergic, infectious, or neoplastic) diseases with distinct pathophysiological pathways. HE may be associated with tissue or organ damage and, in this case, the disorder is classified as hypereosinophilic syndrome (HES). Different studies have allowed for the discovery of two major pathogenetic variants known as myeloid or lymphocytic HES. With the advent of molecular genetic analyses, such as T-cell receptor gene rearrangement assays and Next Generation Sequencing, it is possible to better characterize these syndromes and establish which patients will benefit from pharmacological targeted therapy. In this review, we highlight the molecular alterations that are involved in the pathogenesis of eosinophil disorders and revise possible therapeutic approaches, either implemented in clinical practice or currently under investigation in clinical trials.https://www.mdpi.com/1422-0067/22/2/486hypereosinophiliahypereosinophilic syndromesPDGFRα and PDGFRβ fusionsNGSTCR rearrangements |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefania Stella Michele Massimino Livia Manzella Maria Stella Pennisi Elena Tirrò Chiara Romano Silvia Rita Vitale Adriana Puma Cristina Tomarchio Sandra Di Gregorio Giuseppe Alberto Palumbo Paolo Vigneri |
spellingShingle |
Stefania Stella Michele Massimino Livia Manzella Maria Stella Pennisi Elena Tirrò Chiara Romano Silvia Rita Vitale Adriana Puma Cristina Tomarchio Sandra Di Gregorio Giuseppe Alberto Palumbo Paolo Vigneri Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes International Journal of Molecular Sciences hypereosinophilia hypereosinophilic syndromes PDGFRα and PDGFRβ fusions NGS TCR rearrangements |
author_facet |
Stefania Stella Michele Massimino Livia Manzella Maria Stella Pennisi Elena Tirrò Chiara Romano Silvia Rita Vitale Adriana Puma Cristina Tomarchio Sandra Di Gregorio Giuseppe Alberto Palumbo Paolo Vigneri |
author_sort |
Stefania Stella |
title |
Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes |
title_short |
Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes |
title_full |
Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes |
title_fullStr |
Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes |
title_full_unstemmed |
Molecular Pathogenesis and Treatment Perspectives for Hypereosinophilia and Hypereosinophilic Syndromes |
title_sort |
molecular pathogenesis and treatment perspectives for hypereosinophilia and hypereosinophilic syndromes |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-01-01 |
description |
Hypereosinophilia (HE) is a heterogeneous condition with a persistent elevated eosinophil count of >350/mm<sup>3</sup>, which is reported in various (inflammatory, allergic, infectious, or neoplastic) diseases with distinct pathophysiological pathways. HE may be associated with tissue or organ damage and, in this case, the disorder is classified as hypereosinophilic syndrome (HES). Different studies have allowed for the discovery of two major pathogenetic variants known as myeloid or lymphocytic HES. With the advent of molecular genetic analyses, such as T-cell receptor gene rearrangement assays and Next Generation Sequencing, it is possible to better characterize these syndromes and establish which patients will benefit from pharmacological targeted therapy. In this review, we highlight the molecular alterations that are involved in the pathogenesis of eosinophil disorders and revise possible therapeutic approaches, either implemented in clinical practice or currently under investigation in clinical trials. |
topic |
hypereosinophilia hypereosinophilic syndromes PDGFRα and PDGFRβ fusions NGS TCR rearrangements |
url |
https://www.mdpi.com/1422-0067/22/2/486 |
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