Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial...

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Bibliographic Details
Main Authors: Nadjet Rezki, Amjad M. Al-Yahyawi, Sanaa K. Bardaweel, Fawzia F. Al-Blewi, Mohamed R. Aouad
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
1,3,4-thiadiazole
1,2,4-triazole
1,3,4-oxadiazole
Schiff base
antimicrobial activity
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/20/9/16048

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