Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response
Hormesis is a biphasic dose-response relationship, occurring when low concentrations of toxic agents elicit apparent improvements. In this work, the ability of sub-inhibitory concentrations of Tetracycline to induce hormetic response in a model organism was investigated. To this aim a reference stra...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2013-10-01
|
Series: | Dose-Response |
Online Access: | https://doi.org/10.2203/dose-response.13-002.Migliore |
id |
doaj-51cc50a764e34fcbb347c188c8c88f82 |
---|---|
record_format |
Article |
spelling |
doaj-51cc50a764e34fcbb347c188c8c88f822020-11-25T03:40:52ZengSAGE PublishingDose-Response1559-32582013-10-011110.2203/dose-response.13-002.MiglioreLow Doses of Tetracycline Trigger the Growth: A Case of Hormetic ResponseLuciana MiglioreAlice RotiniMaria Cristina ThallerHormesis is a biphasic dose-response relationship, occurring when low concentrations of toxic agents elicit apparent improvements. In this work, the ability of sub-inhibitory concentrations of Tetracycline to induce hormetic response in a model organism was investigated. To this aim a reference strain of Escherichia coli , MG1655, was exposed to six decreasing doses of Tetracycline (between 0.12 and 0.00375 μg/ml), much lower than the Minimal Inhibitory Concentration (4 μg/ml). An hormetic increase was observed at the intermediate concentrations (0.015–0.03 μg/ml) of the tested range. The Colony Forming Unit number, indeed, rose up to 141% and 121% as compared to the control. At the highest (0.12 μg/ml) and lowest (0.00375 μg/ml) concentrations a slight decrease in CFU number was found. Results demonstrated that, in Escherichia coli , low concentrations of Tetracycline bias the bacterial numerical increase through a hormetic response; the dose-response curve describing this numerical increase is an U-inverted curve. Furthermore, these data confirm that hormesis is common to many - if not all - living systems, including bacteria; they underline the relevance of a deepened knowledge of both the effects and the possible consequences of exposure to low doses of contaminants.https://doi.org/10.2203/dose-response.13-002.Migliore |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luciana Migliore Alice Rotini Maria Cristina Thaller |
spellingShingle |
Luciana Migliore Alice Rotini Maria Cristina Thaller Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response Dose-Response |
author_facet |
Luciana Migliore Alice Rotini Maria Cristina Thaller |
author_sort |
Luciana Migliore |
title |
Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response |
title_short |
Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response |
title_full |
Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response |
title_fullStr |
Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response |
title_full_unstemmed |
Low Doses of Tetracycline Trigger the Growth: A Case of Hormetic Response |
title_sort |
low doses of tetracycline trigger the growth: a case of hormetic response |
publisher |
SAGE Publishing |
series |
Dose-Response |
issn |
1559-3258 |
publishDate |
2013-10-01 |
description |
Hormesis is a biphasic dose-response relationship, occurring when low concentrations of toxic agents elicit apparent improvements. In this work, the ability of sub-inhibitory concentrations of Tetracycline to induce hormetic response in a model organism was investigated. To this aim a reference strain of Escherichia coli , MG1655, was exposed to six decreasing doses of Tetracycline (between 0.12 and 0.00375 μg/ml), much lower than the Minimal Inhibitory Concentration (4 μg/ml). An hormetic increase was observed at the intermediate concentrations (0.015–0.03 μg/ml) of the tested range. The Colony Forming Unit number, indeed, rose up to 141% and 121% as compared to the control. At the highest (0.12 μg/ml) and lowest (0.00375 μg/ml) concentrations a slight decrease in CFU number was found. Results demonstrated that, in Escherichia coli , low concentrations of Tetracycline bias the bacterial numerical increase through a hormetic response; the dose-response curve describing this numerical increase is an U-inverted curve. Furthermore, these data confirm that hormesis is common to many - if not all - living systems, including bacteria; they underline the relevance of a deepened knowledge of both the effects and the possible consequences of exposure to low doses of contaminants. |
url |
https://doi.org/10.2203/dose-response.13-002.Migliore |
work_keys_str_mv |
AT lucianamigliore lowdosesoftetracyclinetriggerthegrowthacaseofhormeticresponse AT alicerotini lowdosesoftetracyclinetriggerthegrowthacaseofhormeticresponse AT mariacristinathaller lowdosesoftetracyclinetriggerthegrowthacaseofhormeticresponse |
_version_ |
1724532463563177984 |