Computational tools for rational protein engineering of aldolases

Computational tools for rational protein engineering of aldolases

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In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This a...

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Bibliographic Details
Main Authors: Michael Widmann, Jürgen Pleiss, Anne K Samland
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Computational and Structural Biotechnology Journal
Subjects:
protein engineering
substrate specificity
stereoselectivity
de novo design
transaldolase
biocatalysis
Online Access:http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209016
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spelling doaj-51d231149fed43d889e48546ecfd2c9e2020-11-24T22:46:38ZengElsevierComputational and Structural Biotechnology Journal2001-03702012-09-0123e201209016Computational tools for rational protein engineering of aldolasesMichael WidmannJürgen PleissAnne K SamlandIn this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209016protein engineeringsubstrate specificitystereoselectivityde novo designtransaldolasebiocatalysis
collection DOAJ
language English
format Article
sources DOAJ
author Michael Widmann
Jürgen Pleiss
Anne K Samland
spellingShingle Michael Widmann
Jürgen Pleiss
Anne K Samland
Computational tools for rational protein engineering of aldolases
Computational and Structural Biotechnology Journal
protein engineering
substrate specificity
stereoselectivity
de novo design
transaldolase
biocatalysis
author_facet Michael Widmann
Jürgen Pleiss
Anne K Samland
author_sort Michael Widmann
title Computational tools for rational protein engineering of aldolases
title_short Computational tools for rational protein engineering of aldolases
title_full Computational tools for rational protein engineering of aldolases
title_fullStr Computational tools for rational protein engineering of aldolases
title_full_unstemmed Computational tools for rational protein engineering of aldolases
title_sort computational tools for rational protein engineering of aldolases
publisher Elsevier
series Computational and Structural Biotechnology Journal
issn 2001-0370
publishDate 2012-09-01
description In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.
topic protein engineering
substrate specificity
stereoselectivity
de novo design
transaldolase
biocatalysis
url http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209016
work_keys_str_mv AT michaelwidmann computationaltoolsforrationalproteinengineeringofaldolases
AT jurgenpleiss computationaltoolsforrationalproteinengineeringofaldolases
AT anneksamland computationaltoolsforrationalproteinengineeringofaldolases
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