Computational tools for rational protein engineering of aldolases

Computational tools for rational protein engineering of aldolases

Show other versions (1)

In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This a...

Full description

Bibliographic Details
Main Authors:	Michael Widmann, Jürgen Pleiss, Anne K Samland
Format:	Article
Language:	English
Published:	Elsevier 2012-09-01
Series:	Computational and Structural Biotechnology Journal
Subjects:	protein engineering substrate specificity stereoselectivity de novo design transaldolase biocatalysis
Online Access:	http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209016

Similar Items

COMPUTATIONAL TOOLS FOR RATIONAL PROTEIN ENGINEERING OF ALDOLASES
by: Michael Widmann, et al.
Published: (2012-09-01)

Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
by: Christopher J. Schofield
Published: (2018-07-01)

Rational engineering of esterases for improved amidase specificity in amide synthesis and hydrolysis
by: Hendil-Forssell, Peter
Published: (2016)

Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes
by: Hamed, Refaat B., et al.
Published: (2019)

New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments
by: Erica Elisa Ferrandi, et al.
Published: (2018-10-01)

Metabolic engineering of F. oxysporum to improve its ethanol-producing capability
by: George E Anasontzis, et al.
Published: (2016-05-01)

Bacterial cytochrome P450-catalyzed regio- and stereoselective steroid hydroxylation enabled by directed evolution and rational design
by: Xiaodong Zhang, et al.
Published: (2020-01-01)

Structure-guided protein engineering of ammonia lyase for efficient synthesis of sterically bulky unnatural amino acids
by: Lou, W.-Y, et al.
Published: (2021)

Development of an Assay System for the Determination of Transketolase and Transaldolase Activities in Hyperthermophilic Bacteria and Archaea
by: Chen, Qing Yun
Published: (2012)

Successful Liver Transplantation in Two Polish Brothers with Transaldolase Deficiency
by: Marek Stefanowicz, et al.
Published: (2021-08-01)

One-Pot Multi-Enzymatic Synthesis of the Four Stereoisomers of 4-Methylheptan-3-ol
by: Elisabetta Brenna, et al.
Published: (2017-09-01)

Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1
by: Michele Crotti, et al.
Published: (2019-04-01)

Advances in Enzymatic Synthesis of D-Amino Acids
by: Loredano Pollegioni, et al.
Published: (2020-05-01)

(S)-Thienyl and (R)-Pirydyl phosphonate Derivatives Synthesized by Stereoselective Resolution of Their Racemic Mixtures With Rhodotorula mucilaginosa (DSM 70403) - Scaling Approaches
by: Katarzyna Lubiak-Kozłowska, et al.
Published: (2020-11-01)

Two (Chemo)-Enzymatic Cascades for the Production of Opposite Enantiomers of Chiral Azidoalcohols
by: Elia Calderini, et al.
Published: (2021-08-01)

Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers
by: Daniel González-Martínez, et al.
Published: (2018-10-01)

Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids
by: Mathias Pickl, et al.
Published: (2017-12-01)

Transaldolase in Bacillus methanolicus: biochemical characterization and biological role in ribulose monophosphate cycle
by: Johannes Pfeifenschneider, et al.
Published: (2020-03-01)

Caracterização biofísica da interação entre o flavonoide Morina e a proteína Transaldolase isolada de Corynebacterium pseudotuberculosis
by: Prado, Ana Karla Miranda [UNESP]
Published: (2017)

Gene mining-based identification of aldo–keto reductases for highly stereoselective reduction of bulky ketones
by: Chen Liang, et al.
Published: (2018-07-01)

Alteration of lipase properties by protein engineering methods
by: Bornscheuer Uwe T.
Published: (2008-05-01)

Self-Immobilizing Biocatalysts Maximize Space–Time Yields in Flow Reactors
by: Theo Peschke, et al.
Published: (2019-02-01)

Computational approaches for rational design of proteins with novel functionalities
by: Manish Kumar Tiwari, et al.
Published: (2012-09-01)

COMPUTATIONAL APPROACHES FOR RATIONAL DESIGN OF PROTEINS WITH NOVEL FUNCTIONALITIES
by: Manish Kumar Tiwari, et al.
Published: (2012-09-01)

Computational Protein Engineering: Bridging the Gap between Rational Design and Laboratory Evolution
by: Shina Caroline Lynn Kamerlin, et al.
Published: (2012-09-01)

Towards practical biocatalytic Baeyer-Villiger reactions: applying a thermostable enzyme in the gram-scale synthesis of optically-active lactones in a two-liquid-phase system
by: Frank Schulz, et al.
Published: (2005-10-01)

FACTORS OF ADHESION OF BIFIDOBACTERIA
by: Yu. V. Zakharova
Published: (2016-10-01)

Catalysis and Site-Specific Modification of Glutathione Transferases Enabled by Rational Design
by: Håkansson Hederos, Sofia
Published: (2005)

Mechanistic Characterization of Transaldolase from <i>Thermoplasma Acidophilum</i> and Preliminary Analysis of the QncN/L-M Protein System from <i>Streptomyces Melanovinaceus</i>
by: Sautner, Viktor
Published: (2018)

Immobilized Whole-Cell Transaminase Biocatalysts for Continuous-Flow Kinetic Resolution of Amines
by: Zsófia Molnár, et al.
Published: (2019-05-01)

Iterative construction of deoxypropionate units : a study of the "Anchor" and "Ester" effects
by: Chahal, Navjot
Published: (2017)

Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions
by: Kateryna Fesko
Published: (2019-05-01)

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme
by: Åsa Janfalk Carlsson, et al.
Published: (2018-05-01)

Corrigendum: Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus: Biochemical and Structural Characterization
by: Michail N. Isupov, et al.
Published: (2019-04-01)

Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus: Biochemical and Structural Characterization
by: Michail N. Isupov, et al.
Published: (2019-01-01)

Reaction Mechanism and Substrate Specificity of Iso-orotate Decarboxylase: A Combined Theoretical and Experimental Study
by: Xiang Sheng, et al.
Published: (2018-12-01)

Progress in Stereoselective Construction of C–C Bonds Enabled by Aldolases and Hydroxynitrile Lyases
by: Mi Liu, et al.
Published: (2021-04-01)

RECENT ADVANCES IN RATIONAL APPROACHES FOR ENZYME ENGINEERING
by: Kerstin Steiner, et al.
Published: (2012-09-01)

Recent advances in rational approaches for enzyme engineering
by: Kerstin Steiner, et al.
Published: (2012-09-01)

Tools for Maximizing the Efficiency of Protein Engineering
by: Polizzi, Karen Marie
Published: (2006)