Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
The SNF1-related protein kinases 1 (SnRK1s) are the plant orthologs of the budding yeast SNF1 (Sucrose Non-Fermenting 1) and mammalian AMPK (AMP-activated protein kinase). These evolutionarily conserved kinases are metabolic sensors that undergo activation in response to declining energy levels. Upo...
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doaj-51d2f3e004bd4f15ae07d7e68826ea4d2020-11-24T21:33:57ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2014-05-01510.3389/fpls.2014.0019083320Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinasesPierre eCrozet0Leonor eMargalha1Ana eConfraria2Américo eRodrigues3Américo eRodrigues4Cláudia eMartinho5Mattia eAdamo6Carlos Alexandre Elias7Elena eBaena-González8Instituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Politécnico de LeiriaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaThe SNF1-related protein kinases 1 (SnRK1s) are the plant orthologs of the budding yeast SNF1 (Sucrose Non-Fermenting 1) and mammalian AMPK (AMP-activated protein kinase). These evolutionarily conserved kinases are metabolic sensors that undergo activation in response to declining energy levels. Upon activation, SNF1/AMPK/SnRK1 kinases trigger a vast transcriptional and metabolic reprogramming that restores energy homeostasis and promotes tolerance to adverse conditions, partly through an induction of catabolic processes and a general repression of anabolism. These kinases typically function as a heterotrimeric complex composed of two regulatory subunits, β and γ, and an α-catalytic subunit, which requires phosphorylation of a conserved activation loop residue for activity. Additionally, SNF1/AMPK/SnRK1 kinases are controlled by multiple mechanisms that have an impact on kinase activity, stability and/or subcellular localization. Here we will review current knowledge on the regulation of SNF1/AMPK/SnRK1 by upstream components, posttranslational modifications, various metabolites, hormones and others, in an attempt to highlight both the commonalities of these essential eukaryotic kinases and the divergences that have evolved to cope with the particularities of each one of these systems.http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00190/fullArabidopsisstressAMPKSnRK1energy signalingSNF1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierre eCrozet Leonor eMargalha Ana eConfraria Américo eRodrigues Américo eRodrigues Cláudia eMartinho Mattia eAdamo Carlos Alexandre Elias Elena eBaena-González |
spellingShingle |
Pierre eCrozet Leonor eMargalha Ana eConfraria Américo eRodrigues Américo eRodrigues Cláudia eMartinho Mattia eAdamo Carlos Alexandre Elias Elena eBaena-González Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases Frontiers in Plant Science Arabidopsis stress AMPK SnRK1 energy signaling SNF1 |
author_facet |
Pierre eCrozet Leonor eMargalha Ana eConfraria Américo eRodrigues Américo eRodrigues Cláudia eMartinho Mattia eAdamo Carlos Alexandre Elias Elena eBaena-González |
author_sort |
Pierre eCrozet |
title |
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases |
title_short |
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases |
title_full |
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases |
title_fullStr |
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases |
title_full_unstemmed |
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases |
title_sort |
mechanisms of regulation of snf1/ampk/snrk1 protein kinases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Plant Science |
issn |
1664-462X |
publishDate |
2014-05-01 |
description |
The SNF1-related protein kinases 1 (SnRK1s) are the plant orthologs of the budding yeast SNF1 (Sucrose Non-Fermenting 1) and mammalian AMPK (AMP-activated protein kinase). These evolutionarily conserved kinases are metabolic sensors that undergo activation in response to declining energy levels. Upon activation, SNF1/AMPK/SnRK1 kinases trigger a vast transcriptional and metabolic reprogramming that restores energy homeostasis and promotes tolerance to adverse conditions, partly through an induction of catabolic processes and a general repression of anabolism. These kinases typically function as a heterotrimeric complex composed of two regulatory subunits, β and γ, and an α-catalytic subunit, which requires phosphorylation of a conserved activation loop residue for activity. Additionally, SNF1/AMPK/SnRK1 kinases are controlled by multiple mechanisms that have an impact on kinase activity, stability and/or subcellular localization. Here we will review current knowledge on the regulation of SNF1/AMPK/SnRK1 by upstream components, posttranslational modifications, various metabolites, hormones and others, in an attempt to highlight both the commonalities of these essential eukaryotic kinases and the divergences that have evolved to cope with the particularities of each one of these systems. |
topic |
Arabidopsis stress AMPK SnRK1 energy signaling SNF1 |
url |
http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00190/full |
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