A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates
High-throughput testing of drugs across molecular-characterised cell lines can identify candidate treatments and discover biomarkers. However, the cells’ response to a drug is typically quantified by a summary statistic from a best-fit dose-response curve, whilst neglecting the uncertainty of the cu...
Main Authors: | Dennis Wang, James Hensman, Ginte Kutkaite, Tzen S Toh, Ana Galhoz, GDSC Screening Team, Jonathan R Dry, Julio Saez-Rodriguez, Mathew J Garnett, Michael P Menden, Frank Dondelinger |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/60352 |
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