The Microbiota and Gut-Related Disorders: Insights from Animal Models

The Microbiota and Gut-Related Disorders: Insights from Animal Models

Over the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions of microbes that exhibit various roles including the production of vitamins, abs...

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Main Authors: Layla Kamareddine, Hoda Najjar, Muhammad Umar Sohail, Hadil Abdulkader, Maha Al-Asmakh
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
animal models
germ-free
gut microbiota
gut-related disorders
host–defense
pathogen virulence
Online Access:https://www.mdpi.com/2073-4409/9/11/2401
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spelling doaj-51d7897aed34400fb995f84282983d952020-11-25T04:02:09ZengMDPI AGCells2073-44092020-11-0192401240110.3390/cells9112401The Microbiota and Gut-Related Disorders: Insights from Animal ModelsLayla Kamareddine0Hoda Najjar1Muhammad Umar Sohail2Hadil Abdulkader3Maha Al-Asmakh4Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, QatarDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, QatarDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, QatarDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, QatarDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, QatarOver the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions of microbes that exhibit various roles including the production of vitamins, absorption of nutrients, pathogen displacement, and development of the host immune system, particular attention has been given to the use of germ-free (GF) animal models in unraveling the effect of the gut microbiota on the physiology and pathophysiology of the host. In this review, we discuss common methods used to generate GF fruit fly, zebrafish,<i> </i>and mice model systems and highlight the use of these GF model organisms in addressing the role of gut-microbiota in gut-related disorders (metabolic diseases, inflammatory bowel disease, and cancer), and in activating host defense mechanisms and amending pathogenic virulence.https://www.mdpi.com/2073-4409/9/11/2401animal modelsgerm-freegut microbiotagut-related disordershost–defensepathogen virulence
collection DOAJ
language English
format Article
sources DOAJ
author Layla Kamareddine
Hoda Najjar
Muhammad Umar Sohail
Hadil Abdulkader
Maha Al-Asmakh
spellingShingle Layla Kamareddine
Hoda Najjar
Muhammad Umar Sohail
Hadil Abdulkader
Maha Al-Asmakh
The Microbiota and Gut-Related Disorders: Insights from Animal Models
Cells
animal models
germ-free
gut microbiota
gut-related disorders
host–defense
pathogen virulence
author_facet Layla Kamareddine
Hoda Najjar
Muhammad Umar Sohail
Hadil Abdulkader
Maha Al-Asmakh
author_sort Layla Kamareddine
title The Microbiota and Gut-Related Disorders: Insights from Animal Models
title_short The Microbiota and Gut-Related Disorders: Insights from Animal Models
title_full The Microbiota and Gut-Related Disorders: Insights from Animal Models
title_fullStr The Microbiota and Gut-Related Disorders: Insights from Animal Models
title_full_unstemmed The Microbiota and Gut-Related Disorders: Insights from Animal Models
title_sort microbiota and gut-related disorders: insights from animal models
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-11-01
description Over the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions of microbes that exhibit various roles including the production of vitamins, absorption of nutrients, pathogen displacement, and development of the host immune system, particular attention has been given to the use of germ-free (GF) animal models in unraveling the effect of the gut microbiota on the physiology and pathophysiology of the host. In this review, we discuss common methods used to generate GF fruit fly, zebrafish,<i> </i>and mice model systems and highlight the use of these GF model organisms in addressing the role of gut-microbiota in gut-related disorders (metabolic diseases, inflammatory bowel disease, and cancer), and in activating host defense mechanisms and amending pathogenic virulence.
topic animal models
germ-free
gut microbiota
gut-related disorders
host–defense
pathogen virulence
url https://www.mdpi.com/2073-4409/9/11/2401
work_keys_str_mv AT laylakamareddine themicrobiotaandgutrelateddisordersinsightsfromanimalmodels
AT hodanajjar themicrobiotaandgutrelateddisordersinsightsfromanimalmodels
AT muhammadumarsohail themicrobiotaandgutrelateddisordersinsightsfromanimalmodels
AT hadilabdulkader themicrobiotaandgutrelateddisordersinsightsfromanimalmodels
AT mahaalasmakh themicrobiotaandgutrelateddisordersinsightsfromanimalmodels
AT laylakamareddine microbiotaandgutrelateddisordersinsightsfromanimalmodels
AT hodanajjar microbiotaandgutrelateddisordersinsightsfromanimalmodels
AT muhammadumarsohail microbiotaandgutrelateddisordersinsightsfromanimalmodels
AT hadilabdulkader microbiotaandgutrelateddisordersinsightsfromanimalmodels
AT mahaalasmakh microbiotaandgutrelateddisordersinsightsfromanimalmodels
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