Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis
Aim of this study : Chemotherapy-induced peripheral neuropathy (CIPN) is a major complication of cancer patients with chemotherapy. Although many interventions have been evaluated in previous studies, findings are controversial. The aim of this meta-analysis is to assess the efficacy of vitamin E su...
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doaj-51e2999775e9446e8e717e27f4588ce42020-11-24T21:00:36ZengTermedia Publishing HouseContemporary Oncology1428-25261897-43092016-08-0120323724110.5114/wo.2016.6156728092Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysisHuaping HuangMei HeLihua LiuLili HuangAim of this study : Chemotherapy-induced peripheral neuropathy (CIPN) is a major complication of cancer patients with chemotherapy. Although many interventions have been evaluated in previous studies, findings are controversial. The aim of this meta-analysis is to assess the efficacy of vitamin E supplementation in preventing CIPN. Material and methods : The electronic databases MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched from their inception to December 31, 2013 to identify relevant randomised controlled trials. Two reviewers independently scanned and extracted the data of included studies. Review Manager 5.2 was used to analyse data. Results : Six articles involving 353 patients were included in meta-analysis. The results showed that vitamin E supplementation did not appear to significantly decrease the incidence of CIPN (relative risk (RR), 0.55; 95% confidence interval (CI), 0.29 to 1.05; p = 0.07), with significant heterogeneity (I2 = 77%). However, Vitamin E supplementation can significantly prevent cisplatin associated neurotoxicity (RR, 0.31; 95%CI, 0.17 to 0.58; p = 0.0002), with no heterogeneity (I2 = 0%). Conclusions : Vitamin E administration dose not decrease the incidence of CIPN. However, additional randomised controlled trials using large samples are needed to confirm the role of vitamin E supplementation.https://www.termedia.pl/Vitamin-E-does-not-decrease-the-incidence-of-chemotherapy-induced-peripheral-neuropathy-a-meta-analysis,3,28092,1,1.htmlvitamin E chemotherapy neuropathy prevention meta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huaping Huang Mei He Lihua Liu Lili Huang |
spellingShingle |
Huaping Huang Mei He Lihua Liu Lili Huang Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis Contemporary Oncology vitamin E chemotherapy neuropathy prevention meta-analysis |
author_facet |
Huaping Huang Mei He Lihua Liu Lili Huang |
author_sort |
Huaping Huang |
title |
Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis |
title_short |
Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis |
title_full |
Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis |
title_fullStr |
Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis |
title_full_unstemmed |
Vitamin E does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis |
title_sort |
vitamin e does not decrease the incidence of chemotherapy-induced peripheral neuropathy: a meta-analysis |
publisher |
Termedia Publishing House |
series |
Contemporary Oncology |
issn |
1428-2526 1897-4309 |
publishDate |
2016-08-01 |
description |
Aim of this study : Chemotherapy-induced peripheral neuropathy (CIPN) is a major complication of cancer patients with chemotherapy. Although many interventions have been evaluated in previous studies, findings are controversial. The aim of this meta-analysis is to assess the efficacy of vitamin E supplementation in preventing CIPN.
Material and methods : The electronic databases MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched from their inception to December 31, 2013 to identify relevant randomised controlled trials. Two reviewers independently scanned and extracted the data of included studies. Review Manager 5.2 was used to analyse data.
Results : Six articles involving 353 patients were included in meta-analysis. The results showed that vitamin E supplementation did not appear to significantly decrease the incidence of CIPN (relative risk (RR), 0.55; 95% confidence interval (CI), 0.29 to 1.05; p = 0.07), with significant heterogeneity (I2 = 77%). However, Vitamin E supplementation can significantly prevent cisplatin associated neurotoxicity (RR, 0.31; 95%CI, 0.17 to 0.58; p = 0.0002), with no heterogeneity (I2 = 0%).
Conclusions : Vitamin E administration dose not decrease the incidence of CIPN. However, additional randomised controlled trials using large samples are needed to confirm the role of vitamin E supplementation. |
topic |
vitamin E chemotherapy neuropathy prevention meta-analysis |
url |
https://www.termedia.pl/Vitamin-E-does-not-decrease-the-incidence-of-chemotherapy-induced-peripheral-neuropathy-a-meta-analysis,3,28092,1,1.html |
work_keys_str_mv |
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