Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema
Introduction. Diabetic retinopathy is the most common cause of visual loss and blindness in the age group of 20 to 64 years. This study aimed to evaluate the efficacy of oral Losartan adjuvant therapy in combination with intravitreal injection of Bevacizumab in the treatment of diabetic macular edem...
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doaj-51e66e23abe847e0bebd591aad7f8b8e2020-11-25T03:41:50ZengHindawi LimitedJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/45284914528491Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular EdemaFariba Ghassemi0Abdulrahim Amini1Masoud Yasemi2Amin Nabavi3Mohammadkarim Johari4Department of Ophthalmology, Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranHormozgan University of Medical Sciences, Bandar Abbas, IranPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranEye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranIntroduction. Diabetic retinopathy is the most common cause of visual loss and blindness in the age group of 20 to 64 years. This study aimed to evaluate the efficacy of oral Losartan adjuvant therapy in combination with intravitreal injection of Bevacizumab in the treatment of diabetic macular edema. Methods. In this randomized clinical trial, 61 eyes of 47 patients with normal blood pressure and diabetic macular edema and nonproliferative diabetic retinopathy were studied. Patients were randomly divided into Losartan (n = 33) and control (n = 28) groups. All patients received 3–6 intravitreal injections of Bevacizumab over 6 months. General examination including blood pressure and glycosylated hemoglobin measurements were performed in all patients. Complete ophthalmologic examination and macular OCT were performed at the first, third, and sixth months of treatment in all patients. Results. The mean age of the patients studied was 57.1 ± 7.4 years and 37.7% of the patients were male. There was no significant difference between the two groups in terms of initial visual acuity, central macular thickness, and frequency of injections. There was no significant difference in visual acuity and central macular thickness between the two groups at the first, third, and sixth months of treatment. Age, frequency of injection, and initial macular thickness less than 450 microns were effective in patients’ final visual acuity. Conclusion. Short-term adjuvant treatment with Losartan in patients with diabetic macular edema and nonproliferative diabetic retinopathy has no greater effect than the standard treatment.http://dx.doi.org/10.1155/2020/4528491 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fariba Ghassemi Abdulrahim Amini Masoud Yasemi Amin Nabavi Mohammadkarim Johari |
spellingShingle |
Fariba Ghassemi Abdulrahim Amini Masoud Yasemi Amin Nabavi Mohammadkarim Johari Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema Journal of Ophthalmology |
author_facet |
Fariba Ghassemi Abdulrahim Amini Masoud Yasemi Amin Nabavi Mohammadkarim Johari |
author_sort |
Fariba Ghassemi |
title |
Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema |
title_short |
Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema |
title_full |
Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema |
title_fullStr |
Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema |
title_full_unstemmed |
Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema |
title_sort |
effect of adding losartan to bevacizumab for treating diabetic macular edema |
publisher |
Hindawi Limited |
series |
Journal of Ophthalmology |
issn |
2090-004X 2090-0058 |
publishDate |
2020-01-01 |
description |
Introduction. Diabetic retinopathy is the most common cause of visual loss and blindness in the age group of 20 to 64 years. This study aimed to evaluate the efficacy of oral Losartan adjuvant therapy in combination with intravitreal injection of Bevacizumab in the treatment of diabetic macular edema. Methods. In this randomized clinical trial, 61 eyes of 47 patients with normal blood pressure and diabetic macular edema and nonproliferative diabetic retinopathy were studied. Patients were randomly divided into Losartan (n = 33) and control (n = 28) groups. All patients received 3–6 intravitreal injections of Bevacizumab over 6 months. General examination including blood pressure and glycosylated hemoglobin measurements were performed in all patients. Complete ophthalmologic examination and macular OCT were performed at the first, third, and sixth months of treatment in all patients. Results. The mean age of the patients studied was 57.1 ± 7.4 years and 37.7% of the patients were male. There was no significant difference between the two groups in terms of initial visual acuity, central macular thickness, and frequency of injections. There was no significant difference in visual acuity and central macular thickness between the two groups at the first, third, and sixth months of treatment. Age, frequency of injection, and initial macular thickness less than 450 microns were effective in patients’ final visual acuity. Conclusion. Short-term adjuvant treatment with Losartan in patients with diabetic macular edema and nonproliferative diabetic retinopathy has no greater effect than the standard treatment. |
url |
http://dx.doi.org/10.1155/2020/4528491 |
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