Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.

Population-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 28...

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Main Authors: Kwai-Fong Lee, Yi-Ting Tsai, Chih-Yuan Lin, Chung-Bao Hsieh, Sheng-Tang Wu, Hung-Yen Ke, Yi-Chang Lin, Feng-Yen Lin, Wei-Hwa Lee, Chien-Sung Tsai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4873185?pdf=render
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spelling doaj-51e7f4c664864a5cb1c15f29b318a33b2020-11-25T02:05:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015560210.1371/journal.pone.0155602Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.Kwai-Fong LeeYi-Ting TsaiChih-Yuan LinChung-Bao HsiehSheng-Tang WuHung-Yen KeYi-Chang LinFeng-Yen LinWei-Hwa LeeChien-Sung TsaiPopulation-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 2847 kidney, and 1748 liver transplant recipients between 2001 and 2012. Standardized incidence ratios and Cox regression models were used. Compared with the general population, the risk of cancer increased 3.8-fold after heart transplantation, 4.1-fold after kidney transplantation and 4.6-fold after liver transplantation. Cancer occurrence showed considerable variation according to transplanted organs. The most common cancers in all transplant patients were cancers of the head and neck, liver, bladder, and kidney and non-Hodgkin lymphoma. Male recipients had an increased risk of cancers of the head and neck and liver, and female kidney recipients had a significant risk of bladder and kidney cancer. The adjusted hazard ratio for any cancer in all recipients was higher in liver transplant recipients compared with that in heart transplant recipients (hazard ratio = 1.5, P = .04). Cancer occurrence varied considerably and posttransplant cancer screening should be performed routinely according to transplanted organ and sex.http://europepmc.org/articles/PMC4873185?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Kwai-Fong Lee
Yi-Ting Tsai
Chih-Yuan Lin
Chung-Bao Hsieh
Sheng-Tang Wu
Hung-Yen Ke
Yi-Chang Lin
Feng-Yen Lin
Wei-Hwa Lee
Chien-Sung Tsai
spellingShingle Kwai-Fong Lee
Yi-Ting Tsai
Chih-Yuan Lin
Chung-Bao Hsieh
Sheng-Tang Wu
Hung-Yen Ke
Yi-Chang Lin
Feng-Yen Lin
Wei-Hwa Lee
Chien-Sung Tsai
Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
PLoS ONE
author_facet Kwai-Fong Lee
Yi-Ting Tsai
Chih-Yuan Lin
Chung-Bao Hsieh
Sheng-Tang Wu
Hung-Yen Ke
Yi-Chang Lin
Feng-Yen Lin
Wei-Hwa Lee
Chien-Sung Tsai
author_sort Kwai-Fong Lee
title Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
title_short Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
title_full Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
title_fullStr Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
title_full_unstemmed Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
title_sort cancer incidence among heart, kidney, and liver transplant recipients in taiwan.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description Population-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 2847 kidney, and 1748 liver transplant recipients between 2001 and 2012. Standardized incidence ratios and Cox regression models were used. Compared with the general population, the risk of cancer increased 3.8-fold after heart transplantation, 4.1-fold after kidney transplantation and 4.6-fold after liver transplantation. Cancer occurrence showed considerable variation according to transplanted organs. The most common cancers in all transplant patients were cancers of the head and neck, liver, bladder, and kidney and non-Hodgkin lymphoma. Male recipients had an increased risk of cancers of the head and neck and liver, and female kidney recipients had a significant risk of bladder and kidney cancer. The adjusted hazard ratio for any cancer in all recipients was higher in liver transplant recipients compared with that in heart transplant recipients (hazard ratio = 1.5, P = .04). Cancer occurrence varied considerably and posttransplant cancer screening should be performed routinely according to transplanted organ and sex.
url http://europepmc.org/articles/PMC4873185?pdf=render
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