Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.
Population-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 28...
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doaj-51e7f4c664864a5cb1c15f29b318a33b2020-11-25T02:05:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015560210.1371/journal.pone.0155602Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan.Kwai-Fong LeeYi-Ting TsaiChih-Yuan LinChung-Bao HsiehSheng-Tang WuHung-Yen KeYi-Chang LinFeng-Yen LinWei-Hwa LeeChien-Sung TsaiPopulation-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 2847 kidney, and 1748 liver transplant recipients between 2001 and 2012. Standardized incidence ratios and Cox regression models were used. Compared with the general population, the risk of cancer increased 3.8-fold after heart transplantation, 4.1-fold after kidney transplantation and 4.6-fold after liver transplantation. Cancer occurrence showed considerable variation according to transplanted organs. The most common cancers in all transplant patients were cancers of the head and neck, liver, bladder, and kidney and non-Hodgkin lymphoma. Male recipients had an increased risk of cancers of the head and neck and liver, and female kidney recipients had a significant risk of bladder and kidney cancer. The adjusted hazard ratio for any cancer in all recipients was higher in liver transplant recipients compared with that in heart transplant recipients (hazard ratio = 1.5, P = .04). Cancer occurrence varied considerably and posttransplant cancer screening should be performed routinely according to transplanted organ and sex.http://europepmc.org/articles/PMC4873185?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kwai-Fong Lee Yi-Ting Tsai Chih-Yuan Lin Chung-Bao Hsieh Sheng-Tang Wu Hung-Yen Ke Yi-Chang Lin Feng-Yen Lin Wei-Hwa Lee Chien-Sung Tsai |
spellingShingle |
Kwai-Fong Lee Yi-Ting Tsai Chih-Yuan Lin Chung-Bao Hsieh Sheng-Tang Wu Hung-Yen Ke Yi-Chang Lin Feng-Yen Lin Wei-Hwa Lee Chien-Sung Tsai Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan. PLoS ONE |
author_facet |
Kwai-Fong Lee Yi-Ting Tsai Chih-Yuan Lin Chung-Bao Hsieh Sheng-Tang Wu Hung-Yen Ke Yi-Chang Lin Feng-Yen Lin Wei-Hwa Lee Chien-Sung Tsai |
author_sort |
Kwai-Fong Lee |
title |
Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan. |
title_short |
Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan. |
title_full |
Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan. |
title_fullStr |
Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan. |
title_full_unstemmed |
Cancer Incidence among Heart, Kidney, and Liver Transplant Recipients in Taiwan. |
title_sort |
cancer incidence among heart, kidney, and liver transplant recipients in taiwan. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Population-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 2847 kidney, and 1748 liver transplant recipients between 2001 and 2012. Standardized incidence ratios and Cox regression models were used. Compared with the general population, the risk of cancer increased 3.8-fold after heart transplantation, 4.1-fold after kidney transplantation and 4.6-fold after liver transplantation. Cancer occurrence showed considerable variation according to transplanted organs. The most common cancers in all transplant patients were cancers of the head and neck, liver, bladder, and kidney and non-Hodgkin lymphoma. Male recipients had an increased risk of cancers of the head and neck and liver, and female kidney recipients had a significant risk of bladder and kidney cancer. The adjusted hazard ratio for any cancer in all recipients was higher in liver transplant recipients compared with that in heart transplant recipients (hazard ratio = 1.5, P = .04). Cancer occurrence varied considerably and posttransplant cancer screening should be performed routinely according to transplanted organ and sex. |
url |
http://europepmc.org/articles/PMC4873185?pdf=render |
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